Modeling-based factor extraction method for determining spatial heterogeneity of Ga-68 EDTA kinetics in brain tumor

Yun Zhou, S. C. Huang, T. Cloughesy, C. K. Hoh, K. Black

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

ROI method used in Ga-68 EDTA PET dynamic study for quantitative determination of brain tumor BBB permeability assumes that the tumor is homogeneous in terms of Ga-68 EDTA kinetics, even though it is known to be highly heterogeneous. It is desirable to examine regions of different kinetics separately. In this study, we have developed an efficient and effective method to separate tissue regions of different Ga-68 EDTA kinetics. The method uses a two-compartment model to extract three principal component factors (vascular component, fast and slow components) from whole-tumor kinetics by model fitting, then each pixel kinetics in the tumor was expressed in terms of these factors by least-square regression to provide factor images. The whole tumor was separated into two regions - one with mainly fast kinetics and one with slow kinetics. The two regions have markedly different uptake and clearance rate. This method has combined the advantage of statistical factor analysis and modeling approach.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium & Medical Imaging Conference
PublisherIEEE
Pages1859-1862
Number of pages4
Volume3
StatePublished - 1996
Externally publishedYes
EventProceedings of the 1996 IEEE Nuclear Science Symposium. Part 1 (of 3) - Anaheim, CA, USA
Duration: Nov 2 1996Nov 9 1996

Other

OtherProceedings of the 1996 IEEE Nuclear Science Symposium. Part 1 (of 3)
CityAnaheim, CA, USA
Period11/2/9611/9/96

Fingerprint

Ethylenediaminetetraacetic acid
Tumors
Brain
Kinetics
Factor analysis
Pixels
Tissue

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Zhou, Y., Huang, S. C., Cloughesy, T., Hoh, C. K., & Black, K. (1996). Modeling-based factor extraction method for determining spatial heterogeneity of Ga-68 EDTA kinetics in brain tumor. In IEEE Nuclear Science Symposium & Medical Imaging Conference (Vol. 3, pp. 1859-1862). IEEE.

Modeling-based factor extraction method for determining spatial heterogeneity of Ga-68 EDTA kinetics in brain tumor. / Zhou, Yun; Huang, S. C.; Cloughesy, T.; Hoh, C. K.; Black, K.

IEEE Nuclear Science Symposium & Medical Imaging Conference. Vol. 3 IEEE, 1996. p. 1859-1862.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zhou, Y, Huang, SC, Cloughesy, T, Hoh, CK & Black, K 1996, Modeling-based factor extraction method for determining spatial heterogeneity of Ga-68 EDTA kinetics in brain tumor. in IEEE Nuclear Science Symposium & Medical Imaging Conference. vol. 3, IEEE, pp. 1859-1862, Proceedings of the 1996 IEEE Nuclear Science Symposium. Part 1 (of 3), Anaheim, CA, USA, 11/2/96.
Zhou Y, Huang SC, Cloughesy T, Hoh CK, Black K. Modeling-based factor extraction method for determining spatial heterogeneity of Ga-68 EDTA kinetics in brain tumor. In IEEE Nuclear Science Symposium & Medical Imaging Conference. Vol. 3. IEEE. 1996. p. 1859-1862
Zhou, Yun ; Huang, S. C. ; Cloughesy, T. ; Hoh, C. K. ; Black, K. / Modeling-based factor extraction method for determining spatial heterogeneity of Ga-68 EDTA kinetics in brain tumor. IEEE Nuclear Science Symposium & Medical Imaging Conference. Vol. 3 IEEE, 1996. pp. 1859-1862
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