Modeling absolute differences in life expectancy with a censored skew-normal regression approach

André Moser, Kerri Clough-Gorr, Marcel Zwahlen, Matthias Egger, Adrian Spoerri, Milo Puhan, Matthias Bopp, Nino Künzli, Fred Paccaud, Michel Oris

Research output: Contribution to journalArticle

Abstract

Parameter estimates from commonly used multivariable parametric survival regression models do not directly quantify differences in years of life expectancy. Gaussian linear regression models give results in terms of absolute mean differences, but are not appropriate in modeling life expectancy, because in many situations time to death has a negative skewed distribution. A regression approach using a skew-normal distribution would be an alternative to parametric survival models in the modeling of life expectancy, because parameter estimates can be interpreted in terms of survival time differences while allowing for skewness of the distribution. In this paper we show how to use the skew-normal regression so that censored and left-truncated observations are accounted for. With this we model differences in life expectancy using data from the Swiss National Cohort Study and from official life expectancy estimates and compare the results with those derived from commonly used survival regression models. We conclude that a censored skew-normal survival regression approach for left-truncated observations can be used to model differences in life expectancy across covariates of interest.

Original languageEnglish (US)
Article numbere1162
JournalPeerJ
Volume2015
Issue number8
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • Censoring
  • Left-truncation
  • Life expectancy
  • Skew-normal regression
  • Survival regression

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Neuroscience(all)

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    Moser, A., Clough-Gorr, K., Zwahlen, M., Egger, M., Spoerri, A., Puhan, M., Bopp, M., Künzli, N., Paccaud, F., & Oris, M. (2015). Modeling absolute differences in life expectancy with a censored skew-normal regression approach. PeerJ, 2015(8), [e1162]. https://doi.org/10.7717/peerj.1162