@article{2a92f699cb0744ddb19f53b5aae4f05b,
title = "Model to estimate effective doses of adsorbed pollutants on respirable particles and their subsequent release into alveolar surfactant. 1. Validation of the model for the adsorption and release of formaldehyde on a respirable carbon black",
abstract = "This report presents a thermodynamic model based upon measurable physicochemical properties of particle and pollutant molecules and their interactions. This model may be used to predict the distribution of volatile pollutants between gas phase and respirable particles in order to estimate the dose of sorbed pollutants for inhalation studies. Experimental validation of the model has been performed using a nose-only exposure system that has been designed and constructed for the generation and coexposure of mice to an oil furnace carbon black and formaldehyde. The model predicts that an insignificant amount of formaldehyde is carried to the distal lung on the surface of this carbon black and that any formaldehyde that is carried on the particle will be released immediately into the alveolar surfactant.",
author = "Risby, {Terence H.} and Sehnert, {Shelley S.} and Jakab, {George J.} and Hemenway, {David R.}",
note = "Funding Information: This research was partially supported by a grant from the National Institutes of Health (ES 03156) and a contract from the Health Effects Institute (HEI). HE1 is an organization that supports the conduct of independent research and is jointly funded by the United States Environmental Protection Agency (EPA) and automobile manufacturers. Publication here implies nothing about the view of the contents by HE1 or its sponsors. HEl{\textquoteright}s Health Review Committee may comment at any time and will evaluate the final report of the project. Additionally, although the work described in this document has been funded in part by the U.S. Environmental Protection Agency under assistance agreement X808859 with HEI, the contents do not necessarily reflect the views and poli-cies of the agency; nor does mention of trade names or commercial products constitute endorsement or recommendation for use.",
year = "1990",
doi = "10.3109/08958379009145256",
language = "English (US)",
volume = "2",
pages = "223--239",
journal = "Inhalation Toxicology",
issn = "0895-8378",
publisher = "Informa Healthcare",
number = "3",
}