@inproceedings{9f59e041f7e14537836a2861bbe00761,
title = "Model of lysis of mural platelet-fibrin thrombi",
abstract = "A model of tissue-type plasminogen activator (t-PA) mediated mural clot lysis has been developed. The model treats the clot as a porous two-phase mixture, and includes mechanisms of kinetics and fluid transport of chemical species, and mechanical property degradation as the fibrin dissolves. The model is consistent with experimental lysis of platelet-fibrin substrates in an in vitro whole blood reperfusion model. Lysis time is predicted to decrease with increasing wall shear stress, and increase with increasing plasminogen activator inhibitor (PAI)-1 concentration.",
author = "Wootton, {D. M.} and Popel, {A. S.} and Alevriadou, {B. R.}",
year = "1999",
month = dec,
day = "1",
language = "English (US)",
isbn = "0780356756",
series = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
publisher = "IEEE",
booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
note = "Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) ; Conference date: 13-10-1999 Through 16-10-1999",
}