Model identification and estimation of organ-function parameters using radioactive tracers and the impulse-response function

Zsolt Szabó, Henning Vosberg, Charles A. Sondhaus, Ludwig E. Feinendegen

Research output: Contribution to journalReview article

Abstract

Examination of the input-output events in functioning organs by the use of the impulse-response function (IRF) for a radioactive tracer is gaining more and more ground in nuclear medicine. This study summarizes the development of deconvolution analysis, laying special stress on the 'model-free' approach. System linearity and time invariance are discussed, and means of eliminating noise in IRFs originating from the input and organ-time-activity curves are outlined. Typical IRFs are illustrated by flow diagrams, time-domain curves, and their representation by Laplace transforms. The cases of nondiffusible and diffusible tracers as well as parenchymally extracted and transported substances are discussed. Methods for the derivation of models and for the calculation of physiologically important parameters from theIRFs are suggested.

Original languageEnglish (US)
Pages (from-to)265-274
Number of pages10
JournalEuropean Journal of Nuclear Medicine
Volume11
Issue number6-7
DOIs
StatePublished - Nov 1 1985
Externally publishedYes

Keywords

  • Impulse response function
  • Model identification
  • Tracer kinetics
  • Transferfunction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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