Model-free parameters from dynamic contrast-enhanced-MRI: Sensitivity to EES volume fraction and bolus timing

John A. Jesberger, Niusha Rafie, Jeffrey L. Duerk, Jeffrey L. Sunshine, Matthew Mendez, Scot C. Remick, Jonathan S. Lewin

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Purpose: To quantify the unknown relative sensitivities of semiquantitative measures from dynamic contrast-enhanced (DCE) MRI to variations in the volume fraction Ve of the extravascular extracellular space (EES), and the duration of the contrast injection. Materials and Methods: Tissue-uptake curves were simulated across various values of F, PS, Ve, and bolus timings, with and without additive noise and at different image re-acquisition rates. From each, the peak of the first derivative (Gpeak), the total uptake after the rapid first phase (CE), and the IAUC were calculated and plotted against F for each experimental condition. Relationships between each measure and the corresponding quantitative measure Ktrans were also examined, particularly for linearity. Results: The highest sensitivity to flow was achieved for shorter bolus timings for Gpeak, CE, and IAUC. G peak and IAUC were most linearly related to Ktrans. The sensitivity to Ve was lowest for Gpeak, followed by IAUC and CE. Long sampling intervals resulted in severe underestimation of G peak, while IAUC was unaffected provided that the limits of integration were properly applied. Gpeak could not be properly calculated in the presence of noise without a prior smoothing of the acquired curves, while IAUC was again unaffected by noise. Conclusion: Gpeak and IAUC are both useful model-free analogs of blood flow (i.e., K trans) for pre- and posttreatment comparisons. Gpeak may be the better choice in cases where larger changes in Ve are likely, but only if sufficient noise reduction and fast image sampling are applied. If Ve is expected to remain stable, IAUC is superior to Gpeak by virtue of its stability in the face of noise and more reliable estimation over a wider range of sampling rates.

Original languageEnglish (US)
Pages (from-to)586-594
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Issue number3
StatePublished - Sep 2006


  • Angiogenesis
  • Diffusible tracers
  • Dynamic contrast-enhanced MRI
  • Methodology
  • Perfusion imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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