Model for end-stage liver disease (MELD) and allocation of donor livers

Russell Wiesner, Erick Edwards, Richard Freeman, Ann Harper, Ray Kim, Patrick Kamath, Walter Kremers, John Lake, Todd Howard, Robert M. Merion, Robert A. Wolfe, Ruud Krom, Paul Colombani, Paige C. Cottingham, Stephen P. Dunn, John J. Fung, Douglas W. Hanto, Sue V. McDiarmid, John M. Rabkin, Lewis W. Teperman & 2 others Jeremiah G. Turcotte, Lynn Rothberg Wegman

Research output: Contribution to journalArticle

Abstract

Background & Aims: A consensus has been reached that liver donor allocation should be based primarily on liver disease severity and that waiting time should not be a major determining factor. Our aim was to assess the capability of the Model for End-Stage Liver Disease (MELD) score to correctly rank potential liver recipients according to their severity of liver disease and mortality risk on the OPTN liver waiting list. Methods: The MELD model predicts liver disease severity based on serum creatinine, serum total bilirubin, and INR and has been shown to be useful in predicting mortality in patients with compensated and decompensated cirrhosis. In this study, we prospectively applied the MELD score to estimate 3-month mortality to 3437 adult liver transplant candidates with chronic liver disease who were added to the OPTN waiting list at 2A or 2B status between November, 1999, and December, 2001. Results: In this study cohort with chronic liver disease, 412 (12%) died during the 3-month follow-up period. Waiting list mortality increased directly in proportion to the listing MELD score. Patients having a MELD score

Original languageEnglish (US)
Pages (from-to)91-96
Number of pages6
JournalGastroenterology
Volume124
Issue number1
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

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End Stage Liver Disease
Liver Diseases
Tissue Donors
Waiting Lists
Liver
Mortality
Chronic Disease
International Normalized Ratio
Serum
Bilirubin
Creatinine
Fibrosis
Cohort Studies
Transplants

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Wiesner, R., Edwards, E., Freeman, R., Harper, A., Kim, R., Kamath, P., ... Wegman, L. R. (2003). Model for end-stage liver disease (MELD) and allocation of donor livers. Gastroenterology, 124(1), 91-96. https://doi.org/10.1053/gast.2003.50016

Model for end-stage liver disease (MELD) and allocation of donor livers. / Wiesner, Russell; Edwards, Erick; Freeman, Richard; Harper, Ann; Kim, Ray; Kamath, Patrick; Kremers, Walter; Lake, John; Howard, Todd; Merion, Robert M.; Wolfe, Robert A.; Krom, Ruud; Colombani, Paul; Cottingham, Paige C.; Dunn, Stephen P.; Fung, John J.; Hanto, Douglas W.; McDiarmid, Sue V.; Rabkin, John M.; Teperman, Lewis W.; Turcotte, Jeremiah G.; Wegman, Lynn Rothberg.

In: Gastroenterology, Vol. 124, No. 1, 01.01.2003, p. 91-96.

Research output: Contribution to journalArticle

Wiesner, R, Edwards, E, Freeman, R, Harper, A, Kim, R, Kamath, P, Kremers, W, Lake, J, Howard, T, Merion, RM, Wolfe, RA, Krom, R, Colombani, P, Cottingham, PC, Dunn, SP, Fung, JJ, Hanto, DW, McDiarmid, SV, Rabkin, JM, Teperman, LW, Turcotte, JG & Wegman, LR 2003, 'Model for end-stage liver disease (MELD) and allocation of donor livers', Gastroenterology, vol. 124, no. 1, pp. 91-96. https://doi.org/10.1053/gast.2003.50016
Wiesner R, Edwards E, Freeman R, Harper A, Kim R, Kamath P et al. Model for end-stage liver disease (MELD) and allocation of donor livers. Gastroenterology. 2003 Jan 1;124(1):91-96. https://doi.org/10.1053/gast.2003.50016
Wiesner, Russell ; Edwards, Erick ; Freeman, Richard ; Harper, Ann ; Kim, Ray ; Kamath, Patrick ; Kremers, Walter ; Lake, John ; Howard, Todd ; Merion, Robert M. ; Wolfe, Robert A. ; Krom, Ruud ; Colombani, Paul ; Cottingham, Paige C. ; Dunn, Stephen P. ; Fung, John J. ; Hanto, Douglas W. ; McDiarmid, Sue V. ; Rabkin, John M. ; Teperman, Lewis W. ; Turcotte, Jeremiah G. ; Wegman, Lynn Rothberg. / Model for end-stage liver disease (MELD) and allocation of donor livers. In: Gastroenterology. 2003 ; Vol. 124, No. 1. pp. 91-96.
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