Model-based analysis of deep brain stimulation of the thalamus

Cameron C. McIntyre, Warren M. Grill, David L. Sherman, Nitish V. Thakor

Research output: Contribution to journalConference article

Abstract

High-frequency (∼150 Hz) deep brain stimulation (DBS) represents a rapidly emerging therapy in the treatment of medically refractory movement disorders. However, fundamental questions remain about the effects of DBS at both the single cell and network levels. We determined the effects of high frequency stimulation of the thalamus using the combination of a finite element model of the DBS electrode, a multi-compartment cable model of a thalamocortical relay neuron, and a large-scale neural network model of the thalamocortical system. The results show that DBS has an excitatory effect on neural elements near the electrode, and this thalamic excitation results in increased cortical activity. This study supports the hypothesis of excitation-induced changes in network activity as a therapeutic mechanism of DBS.

Original languageEnglish (US)
Pages (from-to)2047-2048
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume3
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Keywords

  • Electrode
  • Finite element model
  • Neuron model

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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