Modafinil-induced hippocampal activation in narcolepsy

Yu Kyeong Kim, In Young Yoon, Yoon Kyung Shin, Sang Soo Cho, Sang Eun Kim

Research output: Contribution to journalArticle

Abstract

This study was undertaken to investigate regional metabolic abnormalities and to determine the effects of modafinil in narcoleptics on cerebral glucose metabolism using [18F] fluorodeoxyglucose positron emission tomography (FDG PET). Eight narcoleptic patients participated in the study. Two [18F] FDG PET scans were obtained before and after 2 weeks of modafinil treatment. To identify the effect of modafinil on regional cerebral abnormalities in narcoleptics, pre- and post-treatment PET scans were compared using paired t-statistics with voxel-wised manner. In narcolepsy patients, significant decreases in cerebral glucose metabolism were observed in the midbrain and upper pons, bilateral hypothalamus, posterior thalamus, hippocampus and right parahippocampus as compared with healthy subjects. After treatment, a significant increase in glucose metabolism in the left hippocampus was found in comparison with pre-treatment scan. This study demonstrated that modafinil activates the hippocampus which receives the afferents from hypothalamus, the center of sleep-wake rhythm.

Original languageEnglish (US)
Pages (from-to)91-96
Number of pages6
JournalNeuroscience Letters
Volume422
Issue number2
DOIs
StatePublished - Jul 11 2007
Externally publishedYes

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Keywords

  • F-18 FDG PET
  • Hippocampus
  • Modafinil
  • Narcolepsy

ASJC Scopus subject areas

  • Neuroscience(all)

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