TY - JOUR
T1 - Mobility decline in the elderly relates to lesion accrual in the splenium of the corpus callosum
AU - Moscufo, Nicola
AU - Wolfson, Leslie
AU - Meier, Dominik
AU - Liguori, Maria
AU - Hildenbrand, Peter G.
AU - Wakefield, Dorothy
AU - Schmidt, Julia A.
AU - Pearlson, Godfrey D.
AU - Guttmann, Charles R.G.
N1 - Funding Information:
Acknowledgments Study supported by the National Institute on Aging—AG022092 (LW) and AG022092-01A1S1 (NM)— University of Connecticut Health Center General Clinical Research Center Grant M01 RR06192; NIH 5 P41 RR13218. We wish to thank Istvan Csapo for his expert advice on image analysis and method validation, Yang Duang for expert neuroradiological assistance, Antal Kucsai for assistance with computer network and archiving of digital MR images, Brian Healy for advice on statistical analyses, and Julie Raulukaitis, Greg Book, and Russell Starankewicz for assistance with MR image acquisition and transfer.
PY - 2012/4
Y1 - 2012/4
N2 - In a previous cross-sectional study on baseline data, we demonstrated that the volume of brain white matter hyperintensities (WMH) in the splenium of corpus callosum (SCC) predicted the current mobility function of older persons. The primary aim of this follow-up study was to determine the relation of WMH volume change in SCC (SCC-ΔWMH) with change in mobility measures. A secondary aim was to characterize the global and regional progression of WMH. Mobility function and WMH burden were evaluated at baseline and at 2 years in 77 community-dwelling individuals (baseline age, 82±4). Regional WMH in SCC, as well as genu and body of corpus callosum, subregions of corona radiata, and superior longitudinal fasciculus were determined using a white matter parcellation atlas. The total WMH volume increased 3.3±3.5 ml/year, mainly through enlargement. Significant WMH increases were observed in all selected regions, particularly within the corona radiata. While at baseline and follow-up we observed correlations between WMH burden and several measures of mobility, longitudinal change correlated only with change in chair rise (CR). SCC-ΔWMH showed the highest correlation (r=-0.413, p=0.0002) and was the best regional predictor of CR decline (OR=1.5, r2=0.3). The SCC-ΔWMH was more than five times larger in the CR-decline group compared to the no-decline group (p=0.0003). The SCC-ΔWMH (top quartile) showed a higher sensitivity/specificity for CR decline compared to change in total WMH, 63/88% versus 52/84%, respectively. The findings suggest that accrual of WMHs in posterior areas of the brain supporting inter-hemispheric integration and processing of visual-spatial information is a mechanism contributing to age-related mobility deterioration.
AB - In a previous cross-sectional study on baseline data, we demonstrated that the volume of brain white matter hyperintensities (WMH) in the splenium of corpus callosum (SCC) predicted the current mobility function of older persons. The primary aim of this follow-up study was to determine the relation of WMH volume change in SCC (SCC-ΔWMH) with change in mobility measures. A secondary aim was to characterize the global and regional progression of WMH. Mobility function and WMH burden were evaluated at baseline and at 2 years in 77 community-dwelling individuals (baseline age, 82±4). Regional WMH in SCC, as well as genu and body of corpus callosum, subregions of corona radiata, and superior longitudinal fasciculus were determined using a white matter parcellation atlas. The total WMH volume increased 3.3±3.5 ml/year, mainly through enlargement. Significant WMH increases were observed in all selected regions, particularly within the corona radiata. While at baseline and follow-up we observed correlations between WMH burden and several measures of mobility, longitudinal change correlated only with change in chair rise (CR). SCC-ΔWMH showed the highest correlation (r=-0.413, p=0.0002) and was the best regional predictor of CR decline (OR=1.5, r2=0.3). The SCC-ΔWMH was more than five times larger in the CR-decline group compared to the no-decline group (p=0.0003). The SCC-ΔWMH (top quartile) showed a higher sensitivity/specificity for CR decline compared to change in total WMH, 63/88% versus 52/84%, respectively. The findings suggest that accrual of WMHs in posterior areas of the brain supporting inter-hemispheric integration and processing of visual-spatial information is a mechanism contributing to age-related mobility deterioration.
KW - Aging
KW - Brain
KW - Magnetic resonance imaging
KW - Mobility
KW - Splenium of corpus callosum
KW - White matter hyperintensities
UR - http://www.scopus.com/inward/record.url?scp=84942303188&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942303188&partnerID=8YFLogxK
U2 - 10.1007/s11357-011-9242-4
DO - 10.1007/s11357-011-9242-4
M3 - Article
C2 - 21505765
AN - SCOPUS:84942303188
SN - 0161-9152
VL - 34
SP - 405
EP - 414
JO - AGE
JF - AGE
IS - 2
ER -