Mobile elements and mammalian genome evolution

Prescott L. Deininger, John V. Moran, Mark A. Batzer, Haig H. Kazazian

Research output: Contribution to journalReview articlepeer-review

Abstract

Mobile elements make up large portions of most eukaryotic genomes. They create genetic instability, not only through insertional mutation but also by contributing recombination substrates, both during and long after their insertion. The combination of whole-genome sequences and the development of innovative new assays to test the function of mobile elements have increased our understanding of how these elements mobilize and how their insertion impacts genome diversity and human disease.

Original languageEnglish (US)
Pages (from-to)651-658
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume13
Issue number6
DOIs
StatePublished - Dec 2003
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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