Mobile elements and mammalian genome evolution

Prescott L. Deininger; John V. Moran; Mark A. Batzer; Haig H. Kazazian

doi:10.1016/j.gde.2003.10.013

Mobile elements and mammalian genome evolution

Prescott L. Deininger, John V. Moran, Mark A. Batzer, Haig H. Kazazian

Research output: Contribution to journal › Review article › peer-review

351 Scopus citations

Abstract

Mobile elements make up large portions of most eukaryotic genomes. They create genetic instability, not only through insertional mutation but also by contributing recombination substrates, both during and long after their insertion. The combination of whole-genome sequences and the development of innovative new assays to test the function of mobile elements have increased our understanding of how these elements mobilize and how their insertion impacts genome diversity and human disease.

Original language	English (US)
Pages (from-to)	651-658
Number of pages	8
Journal	Current Opinion in Genetics and Development
Volume	13
Issue number	6
DOIs	https://doi.org/10.1016/j.gde.2003.10.013
State	Published - Dec 2003
Externally published	Yes

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1016/j.gde.2003.10.013

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title = "Mobile elements and mammalian genome evolution",

abstract = "Mobile elements make up large portions of most eukaryotic genomes. They create genetic instability, not only through insertional mutation but also by contributing recombination substrates, both during and long after their insertion. The combination of whole-genome sequences and the development of innovative new assays to test the function of mobile elements have increased our understanding of how these elements mobilize and how their insertion impacts genome diversity and human disease.",

author = "Deininger, {Prescott L.} and Moran, {John V.} and Batzer, {Mark A.} and Kazazian, {Haig H.}",

note = "Funding Information: Research on mobile elements by the authors is supported by National Institutes of Health RO1 GM45668, R01 GM60518, RO1 GM59290, R01 GM45398, National Science Foundation BCS-0218338, Louisiana Board of Regents Millennium Trust Health Excellence Fund HEF (2000-05)-05, (2000-05)-01, (2001-06)-02, the WM Keck Foundation and Louisiana Board of Regents Governor{\textquoteright}s Biotechnology Initiative GBI (2002-005).",

year = "2003",

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doi = "10.1016/j.gde.2003.10.013",

language = "English (US)",

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T1 - Mobile elements and mammalian genome evolution

AU - Deininger, Prescott L.

AU - Moran, John V.

AU - Batzer, Mark A.

AU - Kazazian, Haig H.

N1 - Funding Information: Research on mobile elements by the authors is supported by National Institutes of Health RO1 GM45668, R01 GM60518, RO1 GM59290, R01 GM45398, National Science Foundation BCS-0218338, Louisiana Board of Regents Millennium Trust Health Excellence Fund HEF (2000-05)-05, (2000-05)-01, (2001-06)-02, the WM Keck Foundation and Louisiana Board of Regents Governor’s Biotechnology Initiative GBI (2002-005).

PY - 2003/12

Y1 - 2003/12

N2 - Mobile elements make up large portions of most eukaryotic genomes. They create genetic instability, not only through insertional mutation but also by contributing recombination substrates, both during and long after their insertion. The combination of whole-genome sequences and the development of innovative new assays to test the function of mobile elements have increased our understanding of how these elements mobilize and how their insertion impacts genome diversity and human disease.

AB - Mobile elements make up large portions of most eukaryotic genomes. They create genetic instability, not only through insertional mutation but also by contributing recombination substrates, both during and long after their insertion. The combination of whole-genome sequences and the development of innovative new assays to test the function of mobile elements have increased our understanding of how these elements mobilize and how their insertion impacts genome diversity and human disease.

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JO - Current Opinion in Genetics and Development

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Mobile elements and mammalian genome evolution

Abstract

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