Mobile DNA elements in the generation of diversity and complexity in the brain

Jennifer A. Erwin, Maria C. Marchetto, Fred H. Gage

Research output: Contribution to journalReview article

Abstract

Mobile elements are DNA sequences that can change their position (retrotranspose) within the genome. Although its biological function is largely unappreciated, DNA derived from mobile elements comprises nearly half of the human genome. It has long been thought that neuronal genomes are invariable; however, recent studies have demonstrated that mobile elements actively retrotranspose during neurogenesis, thereby creating genomic diversity between neurons. In addition, mounting data demonstrate that mobile elements are misregulated in certain neurological disorders, including Rett syndrome and schizophrenia.

Original languageEnglish (US)
Pages (from-to)497-506
Number of pages10
JournalNature Reviews Neuroscience
Volume15
Issue number8
DOIs
StatePublished - Aug 2014
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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