Mobile DNA elements in the generation of diversity and complexity in the brain

Jennifer A. Erwin; Maria C. Marchetto; Fred H. Gage

doi:10.1038/nrn3730

Mobile DNA elements in the generation of diversity and complexity in the brain

Jennifer A. Erwin, Maria C. Marchetto, Fred H. Gage

Research output: Contribution to journal › Review article › peer-review

156 Scopus citations

Abstract

Mobile elements are DNA sequences that can change their position (retrotranspose) within the genome. Although its biological function is largely unappreciated, DNA derived from mobile elements comprises nearly half of the human genome. It has long been thought that neuronal genomes are invariable; however, recent studies have demonstrated that mobile elements actively retrotranspose during neurogenesis, thereby creating genomic diversity between neurons. In addition, mounting data demonstrate that mobile elements are misregulated in certain neurological disorders, including Rett syndrome and schizophrenia.

Original language	English (US)
Pages (from-to)	497-506
Number of pages	10
Journal	Nature Reviews Neuroscience
Volume	15
Issue number	8
DOIs	https://doi.org/10.1038/nrn3730
State	Published - Aug 2014
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1038/nrn3730

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title = "Mobile DNA elements in the generation of diversity and complexity in the brain",

abstract = "Mobile elements are DNA sequences that can change their position (retrotranspose) within the genome. Although its biological function is largely unappreciated, DNA derived from mobile elements comprises nearly half of the human genome. It has long been thought that neuronal genomes are invariable; however, recent studies have demonstrated that mobile elements actively retrotranspose during neurogenesis, thereby creating genomic diversity between neurons. In addition, mounting data demonstrate that mobile elements are misregulated in certain neurological disorders, including Rett syndrome and schizophrenia.",

author = "Erwin, {Jennifer A.} and Marchetto, {Maria C.} and Gage, {Fred H.}",

note = "Funding Information: The authors thank M. L. Gage for editorial comments. This work was supported by the G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust grant #2012-PG-MED002, and NIH TR01 MH095741.",

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PY - 2014/8

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N2 - Mobile elements are DNA sequences that can change their position (retrotranspose) within the genome. Although its biological function is largely unappreciated, DNA derived from mobile elements comprises nearly half of the human genome. It has long been thought that neuronal genomes are invariable; however, recent studies have demonstrated that mobile elements actively retrotranspose during neurogenesis, thereby creating genomic diversity between neurons. In addition, mounting data demonstrate that mobile elements are misregulated in certain neurological disorders, including Rett syndrome and schizophrenia.

AB - Mobile elements are DNA sequences that can change their position (retrotranspose) within the genome. Although its biological function is largely unappreciated, DNA derived from mobile elements comprises nearly half of the human genome. It has long been thought that neuronal genomes are invariable; however, recent studies have demonstrated that mobile elements actively retrotranspose during neurogenesis, thereby creating genomic diversity between neurons. In addition, mounting data demonstrate that mobile elements are misregulated in certain neurological disorders, including Rett syndrome and schizophrenia.

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Mobile DNA elements in the generation of diversity and complexity in the brain

Abstract

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