Mn-salen catalysed benzylic C-H activation for the synthesis of aryl [18F]CF3-containing PET probes

L. Carroll; H. L. Evans; A. C. Spivey; E. O. Aboagye

doi:10.1039/c4cc05762g

Mn-salen catalysed benzylic C-H activation for the synthesis of aryl [¹⁸F]CF₃-containing PET probes

L. Carroll, H. L. Evans, A. C. Spivey, E. O. Aboagye

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The development of a Mn-salen complex catalysed oxidative benzylic fluorination of non-activated C-H bonds using [¹⁸F]fluoride is described for installation of [¹⁸F]CHRF, [¹⁸F]CR₂F and particularly [¹⁸F]CF₃ containing groups in the presence of other functional groups.

Original language	English (US)
Pages (from-to)	8439-8441
Number of pages	3
Journal	Chemical Communications
Volume	51
Issue number	40
DOIs	https://doi.org/10.1039/c4cc05762g
State	Published - May 18 2015
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Mn-salen catalysed benzylic C-H activation for the synthesis of aryl [18F]CF3-containing PET probes",

abstract = "The development of a Mn-salen complex catalysed oxidative benzylic fluorination of non-activated C-H bonds using [18F]fluoride is described for installation of [18F]CHRF, [18F]CR2F and particularly [18F]CF3 containing groups in the presence of other functional groups.",

author = "L. Carroll and Evans, {H. L.} and Spivey, {A. C.} and Aboagye, {E. O.}",

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T1 - Mn-salen catalysed benzylic C-H activation for the synthesis of aryl [18F]CF3-containing PET probes

AU - Carroll, L.

AU - Evans, H. L.

AU - Spivey, A. C.

AU - Aboagye, E. O.

PY - 2015/5/18

Y1 - 2015/5/18

N2 - The development of a Mn-salen complex catalysed oxidative benzylic fluorination of non-activated C-H bonds using [18F]fluoride is described for installation of [18F]CHRF, [18F]CR2F and particularly [18F]CF3 containing groups in the presence of other functional groups.

AB - The development of a Mn-salen complex catalysed oxidative benzylic fluorination of non-activated C-H bonds using [18F]fluoride is described for installation of [18F]CHRF, [18F]CR2F and particularly [18F]CF3 containing groups in the presence of other functional groups.

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Mn-salen catalysed benzylic C-H activation for the synthesis of aryl [¹⁸F]CF₃-containing PET probes

Abstract

ASJC Scopus subject areas

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