Mitotic origins of chromosomal instability in colorectal cancer

W. Brian Dalton; Vincent W. Yang

doi:10.1007/s11888-007-0001-y

Mitotic origins of chromosomal instability in colorectal cancer

W. Brian Dalton, Vincent W. Yang

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Mitosis is a crucial part of the cell cycle. A successful mitosis requires the proper execution of many complex cellular behaviors. Thus, there are many points at which mitosis may be disrupted. In cancer cells, chronic disruption of mitosis can lead to unequal segregation of chromosomes, a phenomenon known as chromosomal instability. A majority of colorectal tumors suffer from this instability, and recent studies have begun to reveal the specific ways in which mitotic defects promote chromosomal instability in colorectal cancer.

Original language	English (US)
Pages (from-to)	59-64
Number of pages	6
Journal	Current Colorectal Cancer Reports
Volume	3
Issue number	2
DOIs	https://doi.org/10.1007/s11888-007-0001-y
State	Published - May 2007
Externally published	Yes

ASJC Scopus subject areas

Hepatology
Oncology
Gastroenterology

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10.1007/s11888-007-0001-y

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title = "Mitotic origins of chromosomal instability in colorectal cancer",

abstract = "Mitosis is a crucial part of the cell cycle. A successful mitosis requires the proper execution of many complex cellular behaviors. Thus, there are many points at which mitosis may be disrupted. In cancer cells, chronic disruption of mitosis can lead to unequal segregation of chromosomes, a phenomenon known as chromosomal instability. A majority of colorectal tumors suffer from this instability, and recent studies have begun to reveal the specific ways in which mitotic defects promote chromosomal instability in colorectal cancer.",

author = "Dalton, {W. Brian} and Yang, {Vincent W.}",

note = "Funding Information: This work was in part support by grants from the National Institutes of Health (DK52230 and CA84197). Dr. Yang was a recipient of a Georgian Cancer Coalition Distinguished Cancer Clinician Scientist Award.",

year = "2007",

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AU - Yang, Vincent W.

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PY - 2007/5

Y1 - 2007/5

N2 - Mitosis is a crucial part of the cell cycle. A successful mitosis requires the proper execution of many complex cellular behaviors. Thus, there are many points at which mitosis may be disrupted. In cancer cells, chronic disruption of mitosis can lead to unequal segregation of chromosomes, a phenomenon known as chromosomal instability. A majority of colorectal tumors suffer from this instability, and recent studies have begun to reveal the specific ways in which mitotic defects promote chromosomal instability in colorectal cancer.

AB - Mitosis is a crucial part of the cell cycle. A successful mitosis requires the proper execution of many complex cellular behaviors. Thus, there are many points at which mitosis may be disrupted. In cancer cells, chronic disruption of mitosis can lead to unequal segregation of chromosomes, a phenomenon known as chromosomal instability. A majority of colorectal tumors suffer from this instability, and recent studies have begun to reveal the specific ways in which mitotic defects promote chromosomal instability in colorectal cancer.

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ER -

Mitotic origins of chromosomal instability in colorectal cancer

Abstract

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