Mitotic origins of chromosomal instability in colorectal cancer

W. Brian Dalton, Vincent W. Yang

Research output: Contribution to journalArticlepeer-review

Abstract

Mitosis is a crucial part of the cell cycle. A successful mitosis requires the proper execution of many complex cellular behaviors. Thus, there are many points at which mitosis may be disrupted. In cancer cells, chronic disruption of mitosis can lead to unequal segregation of chromosomes, a phenomenon known as chromosomal instability. A majority of colorectal tumors suffer from this instability, and recent studies have begun to reveal the specific ways in which mitotic defects promote chromosomal instability in colorectal cancer.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalCurrent Colorectal Cancer Reports
Volume3
Issue number2
DOIs
StatePublished - May 2007
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Oncology
  • Gastroenterology

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