Mitotic membrane helps to focus and stabilize the mitotic spindle

Christopher C. Poirier, Yixian Zheng, Pablo A. Iglesias

Research output: Contribution to journalArticlepeer-review

Abstract

During mitosis, microtubules (MTs), aided by motors and associated proteins, assemble into a mitotic spindle. Recent evidence supports the notion that a membranous spindle matrix aids spindle formation; however, the mechanisms by which the matrix may contribute to spindle assembly are unknown. To search for a mechanism by which the presence of a mitotic membrane might help spindle morphology, we built a computational model that explores the interactions between these components. We show that an elastic membrane around the mitotic apparatus helps to focus MT minus ends and provides a resistive force that acts antagonistically to plus-end-directed MT motors such as Eg5.

Original languageEnglish (US)
Pages (from-to)3182-3190
Number of pages9
JournalBiophysical journal
Volume99
Issue number10
DOIs
StatePublished - Nov 17 2010

ASJC Scopus subject areas

  • Biophysics

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