Mitotic index does not predict prognosis in stage IA non-small cell lung cancer

J. M A Daniels, J. P. Eerenberg, H. Rijna, J. A. Kummer, M. A M Broeckaert, M. A. Paul, P. J. van Diest, J. C. van Mourik

Research output: Contribution to journalArticle

Abstract

Despite radical resection, many patients with stage IA non-small cell lung cancer (NSCLC) die of metastatic disease, showing that apparently there were already micrometastases at the time of surgery. To identify patients at risk for metastatic disease, accurate prognostic factors are needed. Because the mitotic activity index (MAI) is of good prognostic value in several other cancers, we assessed its value in stage IA NSCLC. We assessed the MAI in the sections of 133 patients with radically resected stage IA NSCLC. MAI, histologic subtype, age, sex, location of tumor, type of surgery and tumor diameter were correlated with survival. The mean MAI was 29, ranging from 0 to 89. MAI was not correlated to histologic tumor type or lymph node sample procedure, or any of the other clinicopathologic features. No correlation was found between MAI and survival. Univariate analysis showed that only age was a significant predictor of survival (P=0.0007). This was confirmed by multivariate analysis. The mitotic index is not a predictor of prognosis in stage IA NSCLC. Therefore other prognostic factors have to be investigated.

Original languageEnglish (US)
Pages (from-to)163-167
Number of pages5
JournalLung Cancer
Volume38
Issue number2
DOIs
StatePublished - Nov 1 2002
Externally publishedYes

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Mitotic Index
Non-Small Cell Lung Carcinoma
Survival
Neoplasms
Neoplasm Micrometastasis
Multivariate Analysis
Lymph Nodes

Keywords

  • Lung cancer
  • Mitosis
  • Mitotic index
  • Non-small cell lung cancer
  • Prognostic factor
  • Proliferation
  • Survival

ASJC Scopus subject areas

  • Oncology

Cite this

Daniels, J. M. A., Eerenberg, J. P., Rijna, H., Kummer, J. A., Broeckaert, M. A. M., Paul, M. A., ... van Mourik, J. C. (2002). Mitotic index does not predict prognosis in stage IA non-small cell lung cancer. Lung Cancer, 38(2), 163-167. https://doi.org/10.1016/S0169-5002(02)00215-5

Mitotic index does not predict prognosis in stage IA non-small cell lung cancer. / Daniels, J. M A; Eerenberg, J. P.; Rijna, H.; Kummer, J. A.; Broeckaert, M. A M; Paul, M. A.; van Diest, P. J.; van Mourik, J. C.

In: Lung Cancer, Vol. 38, No. 2, 01.11.2002, p. 163-167.

Research output: Contribution to journalArticle

Daniels, JMA, Eerenberg, JP, Rijna, H, Kummer, JA, Broeckaert, MAM, Paul, MA, van Diest, PJ & van Mourik, JC 2002, 'Mitotic index does not predict prognosis in stage IA non-small cell lung cancer', Lung Cancer, vol. 38, no. 2, pp. 163-167. https://doi.org/10.1016/S0169-5002(02)00215-5
Daniels JMA, Eerenberg JP, Rijna H, Kummer JA, Broeckaert MAM, Paul MA et al. Mitotic index does not predict prognosis in stage IA non-small cell lung cancer. Lung Cancer. 2002 Nov 1;38(2):163-167. https://doi.org/10.1016/S0169-5002(02)00215-5
Daniels, J. M A ; Eerenberg, J. P. ; Rijna, H. ; Kummer, J. A. ; Broeckaert, M. A M ; Paul, M. A. ; van Diest, P. J. ; van Mourik, J. C. / Mitotic index does not predict prognosis in stage IA non-small cell lung cancer. In: Lung Cancer. 2002 ; Vol. 38, No. 2. pp. 163-167.
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