Mitotic-exit control as an evolved complex system

William J. Bosl, Rong Li

Research output: Contribution to journalReview articlepeer-review

Abstract

The exit from mitosis is the last critical decision during a cell-division cycle. A complex regulatory system has evolved to evaluate the success of mitotic events and control this decision. Whereas outstanding genetic work in yeast has led to rapid discovery of a large number of interacting genes involved in the control of mitotic exit, it has also become increasingly difficult to comprehend the logic and mechanistic features embedded in the complex molecular network. Our view is that this difficulty stems in part from the attempt to explain mitotic-exit control using concepts from traditional top-down engineering design, and that exciting new results from evolutionary engineering design applied to networks and electronic circuits may lend better insights. We focus on four particularly intriguing features of the mitotic-exit control system and attempt to examine these features from the perspective of evolutionary design and complex system engineering.

Original languageEnglish (US)
Pages (from-to)325-333
Number of pages9
JournalCell
Volume121
Issue number3
DOIs
StatePublished - May 6 2005

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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