Mitoregulin Controls β-Oxidation in Human and Mouse Adipocytes

Max Friesen, Curtis R. Warren, Haojie Yu, Takafumi Toyohara, Qiurong Ding, Mary H.C. Florido, Carolyn Sayre, Benjamin D. Pope, Loyal A. Goff, John L. Rinn, Chad A. Cowan

Research output: Contribution to journalArticlepeer-review

Abstract

Cowan and colleagues have demonstrated the expression of mitoregulin (MTLN) in murine adipose tissue as well as human stem cell-derived adipocytes. MTLN affects triglyceride accumulation and lipolysis in adipocytes. It does so through mitochondrial localization and interaction with complexes involved in fatty acid oxidation.

Original languageEnglish (US)
Pages (from-to)590-602
Number of pages13
JournalStem Cell Reports
Volume14
Issue number4
DOIs
StatePublished - Apr 14 2020

Keywords

  • MTLN
  • adipocyte
  • human stem cells
  • metabolic disease
  • metabolism
  • mitochondrial metabolism

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

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