Mitomycin C reduces corneal light scattering after excimer keratectomy

S. Jain, R. L. McCally, P. J. Connolly, D. T. Azar

Research output: Contribution to journalArticle

Abstract

Purpose. To evaluate the effect of intraoperative mitomycin C (MMC) on corneal light scattering after excimer laser keratectomy. Methods. Phototherapeutic keratectomy (PTK) was performed in 24 rabbit eyes. After 40-μm epithelial ablation, animals were divided into three groups. In group 1, filter paper discs soaked with MMC (group 1A, 0.5 mg/mL; group 1B, 0.25 mg/ml) were applied for 1 minute. In group 2, annular filter papers soaked with MMC (group 2A, 0.5 mg/mL; group 2B, 0.25 mg/mL) were applied for 1 minute. Controls received vehicle only (group 3). Six-millimeter diameter 100-μm deep PTK was performed. Corneal light scattering was measured weekly from 1 to 6 weeks, at 10 weeks, and at 8 and 13 months using a scatterometer. A corneal light scattering index (SI) ranging from 0 to 10 was calculated; SI of 1 represents normal scattering. Results. A statistically significant decrease in mean SI was noted in group 2A (annular MMC 0.5 mg/mL; p < 0.05) as compared with the control group at 2 weeks. At 10 weeks, SI approached baseline levels in group 2 and the control group but showed significant increase in group 1 (MMC disc; p < 0.05). At 8 and 13 months, SI showed no statistical differences between groups. Conclusions. Controlled application of 0.5 mg/mL MMC in the corneal midperiphery transiently reduces corneal light scattering after excimer keratectomy in this rabbit model.

Original languageEnglish (US)
Pages (from-to)45-49
Number of pages5
JournalCornea
Volume20
Issue number1
DOIs
StatePublished - Jan 16 2001

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Keywords

  • Corneal scar
  • Excimer laser
  • Keratectomy
  • Mitomycin
  • Rabbits
  • Wound healing

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Jain, S., McCally, R. L., Connolly, P. J., & Azar, D. T. (2001). Mitomycin C reduces corneal light scattering after excimer keratectomy. Cornea, 20(1), 45-49. https://doi.org/10.1097/00003226-200101000-00009