Mitochondrial network energetics in the heart

Miguel A. Aon, Sonia Cortassa

Research output: Contribution to journalArticle

Abstract

At the core of eukaryotic aerobic life, mitochondrial function like 'hubs' in the web of energetic and redox processes in cells. In the heart, these networks-extending beyond the complex connectivity of biochemical circuit diagrams and apparent morphology-exhibit collective dynamics spanning several spatiotemporal levels of organization, from the cell, to the tissue, and the organ. The network function of mitochondria, i.e., mitochondrial network energetics, represents an advantageous behavior. Its coordinated action, under normal physiology, provides robustness despite failure in a few nodes, and improves energy supply toward a swiftly changing demand. Extensive diffuse loops, encompassing mitochondrial-cytoplasmic reaction/transport networks, control and regulate energy supply and demand in the heart. Under severe energy crises, the network behavior of mitochondria and associated glycolytic and other metabolic networks collapse, thereby triggering fatal arrhythmias.

Original languageEnglish (US)
Pages (from-to)599-613
Number of pages15
JournalWiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume4
Issue number6
DOIs
StatePublished - Nov 2012

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Mitochondria
Physiology
Metabolic Networks and Pathways
Oxidation-Reduction
Cardiac Arrhythmias
Tissue
Networks (circuits)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Medicine (miscellaneous)

Cite this

Mitochondrial network energetics in the heart. / Aon, Miguel A.; Cortassa, Sonia.

In: Wiley Interdisciplinary Reviews: Systems Biology and Medicine, Vol. 4, No. 6, 11.2012, p. 599-613.

Research output: Contribution to journalArticle

Aon, Miguel A. ; Cortassa, Sonia. / Mitochondrial network energetics in the heart. In: Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 2012 ; Vol. 4, No. 6. pp. 599-613.
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