Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer

Suhail K. Mithani, Janis M. Taube, Shaoyu Zhou, Ian M. Smith, Wayne M. Koch, William H. Westra, Joseph A. Califano

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To determine the timing of mitochondrial mutations in the progression of head and neck squamous cell carcinoma. Experimental Design: Twenty-three mitochondrial mutations were identified in 12 tumors using a high-throughput mitochondrial sequencing array. Areas of adjacent dysplastic and normal epithelium adjacent to tumors were sequenced using conventional methods for the presence of mutations that occurred in the corresponding tumor. Results: Two of 23 (8.7%) tumor mitochondrial mutations (2 of 12 tumors) were present in both the areas of adjacent dysplasia and normal epithelium. Five of 23 (21.7%) tumor mitochondrial mutations (4 of 12 tumors) were present in areas of adjacent dysplasia. Eleven of 12 tumors contained nonsynonymous mutations that resulted in protein coding alterations. A significant difference (P < 0.01, χ2) was found in the incidence of mitochondrial mutation that occurred after development of cancer compared with adjacent areas dysplasia and normal epithelium. Conclusions: The majority of mitochondrial mutations occur during or after the transition of preneoplastic epithelium to cancer in head and neck squamous cell carcinoma, indicating that these are a late event in head and neck carcinogenesis.

Original languageEnglish (US)
Pages (from-to)4331-4335
Number of pages5
JournalClinical Cancer Research
Volume13
Issue number15
DOIs
StatePublished - Aug 1 2007

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer'. Together they form a unique fingerprint.

Cite this