Mitochondrial dysfunction in HIV-induced peripheral neuropathy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mitochondria play an essential role in cellular energy production and calcium homeostasis. Abnormalities in mitochondrial homeostasis and function are seen in several acquired as well as genetic neuropathies, emphasizing their prominent role in neuronal cell activities. Chronic infection with HIV, even when appropriately treated, is a risk factor for developing peripheral neuropathy. In this chapter, we discuss the way in which HIV infection, the resultant toxic viral products that are generated, and some of the viral inhibitors used in its treatment may lead to abnormal mitochondrial function. Of importance are the effects on mitochondrial DNA replication and the neurotoxic effects of the viral gp120 protein. One aspect of mitochondrial dysfunction that remains unexplored is the role of the interaction between mitochondria and the endoplasmic reticulum as a possible target of disruption in HIV neuropathy.

Original languageEnglish (US)
Title of host publicationInternational Review of Neurobiology
PublisherAcademic Press Inc.
DOIs
StatePublished - Jan 1 2019

Publication series

NameInternational Review of Neurobiology
ISSN (Print)0074-7742
ISSN (Electronic)2162-5514

Keywords

  • gp120
  • HIV neuropathy
  • Mitochondrial neuropathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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  • Cite this

    Roda, R., & Hoke, A. (2019). Mitochondrial dysfunction in HIV-induced peripheral neuropathy. In International Review of Neurobiology (International Review of Neurobiology). Academic Press Inc.. https://doi.org/10.1016/bs.irn.2019.04.001