Mitochondrial dynamics in neurodegeneration

Kie Itoh, Ken Nakamura, Miho Iijima, Hiromi Sesaki

Research output: Contribution to journalReview article

Abstract

It has been only 15 years since studies began on the molecular mechanisms underlying mitochondrial fission and fusion using simple model organisms such as Drosophila, yeast, and Caenorhabditis elegans. Beyond the primary functions of mitochondrial fission and fusion in controlling organelle shape, size, and number, it became clear that these dynamic processes are also critical to regulating cell death, mitophagy, and organelle distribution. Now, studies suggest that prominent changes occur in mitochondrial dynamics in a broad array of neurodegenerative diseases, and there is substantial evidence suggesting a key role in disease pathogenesis because neurons are among the most energy-consuming cell types and have a highly developed cell shape. Here, we review the recent findings on mitochondrial dynamics in neurodegeneration.

Original languageEnglish (US)
Pages (from-to)64-71
Number of pages8
JournalTrends in Cell Biology
Volume23
Issue number2
DOIs
StatePublished - Feb 1 2013

Keywords

  • Dynamin-related GTPase
  • Fission
  • Fusion
  • Mitochondria
  • Neurodegeneration

ASJC Scopus subject areas

  • Cell Biology

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