Mitochondrial division: Molecular machinery and physiological functions

Yusuke Kageyama, Zhongyan Zhang, Hiromi Sesaki

Research output: Contribution to journalReview articlepeer-review

Abstract

Mitochondrial division has emerged as a key mechanism for this essential organelle to maintain its structural integrity, intracellular distribution, and functional competence. An evolutionarily conserved dynamin-related GTPase, Dnm1p/Drp1, interacts with other proteins to form the core machinery involved in mitochondrial division. We summarize recent progress in understanding how the division machinery assembles onto mitochondria and how mitochondrial division contributes to cellular physiology and human diseases.

Original languageEnglish (US)
Pages (from-to)427-434
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume23
Issue number4
DOIs
StatePublished - Aug 2011

ASJC Scopus subject areas

  • Cell Biology

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