Mitochondrial division and fusion in metabolism

Madhuparna Roy; P. Hemachandra Reddy; Miho Iijima; Hiromi Sesaki

doi:10.1016/j.ceb.2015.02.001

Mitochondrial division and fusion in metabolism

Madhuparna Roy, P. Hemachandra Reddy, Miho Iijima, Hiromi Sesaki

School of Medicine

Research output: Contribution to journal › Review article › peer-review

111 Scopus citations

Abstract

Mitochondria govern many metabolic processes. In addition, mitochondria sense the status of metabolism and change their functions to regulate energy production, cell death, and thermogenesis. Recent studies have revealed that mitochondrial structural remodeling through division and fusion is critical to the organelle's function. It has also become clear that abnormalities in mitochondrial division and fusion are linked to the pathophysiology of metabolic diseases such as diabetes and obesity. Here, we discuss the current understanding of the mechanisms of mitochondrial dynamics and their role in cellular and organismal metabolism.

Original language	English (US)
Pages (from-to)	111-118
Number of pages	8
Journal	Current Opinion in Cell Biology
Volume	33
DOIs	https://doi.org/10.1016/j.ceb.2015.02.001
State	Published - Apr 1 2015

ASJC Scopus subject areas

Cell Biology

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10.1016/j.ceb.2015.02.001

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title = "Mitochondrial division and fusion in metabolism",

abstract = "Mitochondria govern many metabolic processes. In addition, mitochondria sense the status of metabolism and change their functions to regulate energy production, cell death, and thermogenesis. Recent studies have revealed that mitochondrial structural remodeling through division and fusion is critical to the organelle's function. It has also become clear that abnormalities in mitochondrial division and fusion are linked to the pathophysiology of metabolic diseases such as diabetes and obesity. Here, we discuss the current understanding of the mechanisms of mitochondrial dynamics and their role in cellular and organismal metabolism.",

author = "Madhuparna Roy and Reddy, {P. Hemachandra} and Miho Iijima and Hiromi Sesaki",

note = "Funding Information: We are grateful to many scientists who have contributed to our understanding of mitochondrial division and fusion, and apologize that we were not able to cite all of the relevant publications due to space limitation. This work was supported by NIH grants GM084015 (M.I.), AG042178 (P.H.R.), AG047812 (P.H.R.), GM089853 (H.S.) and NS084154 (H.S.). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

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AU - Roy, Madhuparna

AU - Reddy, P. Hemachandra

AU - Iijima, Miho

AU - Sesaki, Hiromi

N1 - Funding Information: We are grateful to many scientists who have contributed to our understanding of mitochondrial division and fusion, and apologize that we were not able to cite all of the relevant publications due to space limitation. This work was supported by NIH grants GM084015 (M.I.), AG042178 (P.H.R.), AG047812 (P.H.R.), GM089853 (H.S.) and NS084154 (H.S.). Publisher Copyright: © 2015 Elsevier Ltd.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Mitochondria govern many metabolic processes. In addition, mitochondria sense the status of metabolism and change their functions to regulate energy production, cell death, and thermogenesis. Recent studies have revealed that mitochondrial structural remodeling through division and fusion is critical to the organelle's function. It has also become clear that abnormalities in mitochondrial division and fusion are linked to the pathophysiology of metabolic diseases such as diabetes and obesity. Here, we discuss the current understanding of the mechanisms of mitochondrial dynamics and their role in cellular and organismal metabolism.

AB - Mitochondria govern many metabolic processes. In addition, mitochondria sense the status of metabolism and change their functions to regulate energy production, cell death, and thermogenesis. Recent studies have revealed that mitochondrial structural remodeling through division and fusion is critical to the organelle's function. It has also become clear that abnormalities in mitochondrial division and fusion are linked to the pathophysiology of metabolic diseases such as diabetes and obesity. Here, we discuss the current understanding of the mechanisms of mitochondrial dynamics and their role in cellular and organismal metabolism.

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DO - 10.1016/j.ceb.2015.02.001

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JO - Current Opinion in Cell Biology

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Mitochondrial division and fusion in metabolism

Abstract

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