Mitochondrial building blocks

Robert E. Jensen, Cory D. Dunn, Matt J. Youngman, Hiromi Sesaki

Research output: Contribution to journalShort surveypeer-review

Abstract

Despite many genomic and proteomic attempts, approximately half of all mitochondrial proteins remain unidentified. Moreover, the composition of mitochondria varies in different mammalian cell types and the details of this tissue specificity are unclear. Two recent reports provide a major advance in our understanding of mitochondrial function. Sickmann et al. used an exhaustive proteomic approach and came very close to identifying the complete set of yeast mitochondrial proteins. Mootha et al. examined mitochondria from mouse brain, heart, kidney and liver cells, finding that a surprising fraction of the proteins are expressed in only a subset of tissues.

Original languageEnglish (US)
Pages (from-to)215-218
Number of pages4
JournalTrends in Cell Biology
Volume14
Issue number5
DOIs
StatePublished - May 2004

ASJC Scopus subject areas

  • Cell Biology

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