Mitochondria and neuroplasticity

Aiwu Cheng, Yan Hou, Mark P. Mattson

Research output: Contribution to journalArticle

Abstract

The production of neurons from neural progenitor cells, the growth of axons and dendrites and the formation and reorganization of synapses are examples of neuroplasticity. These processes are regulated by cell-autonomous and intercellular (paracrine and endocrine) programs that mediate responses of neural cells to environmental input. Mitochondria are highly mobile and move within and between subcellular compartments involved in neuroplasticity (synaptic terminals, dendrites, cell body and the axon). By generating energy (ATP and NAD+), and regulating subcellular Ca2+ and redox homoeostasis, mitochondria may play important roles in controlling fundamental processes in neuroplasticity, including neural differentiation, neurite outgrowth, neurotransmitter release and dendritic remodelling. Particularly intriguing is emerging data suggesting that mitochondria emit molecular signals (e.g. reactive oxygen species, proteins and lipid mediators) that can act locally or travel to distant targets including the nucleus. Disturbances in mitochondrial functions and signalling may play roles in impaired neuroplasticity and neuronal degeneration in Alzheimer's disease, Parkinson's disease, psychiatric disorders and stroke.

Original languageEnglish (US)
Article numbere00045
Pages (from-to)243-256
Number of pages14
JournalASN Neuro
Volume2
Issue number5
DOIs
StatePublished - 2010

Fingerprint

Neuronal Plasticity
Mitochondria
Dendrites
Axons
Presynaptic Terminals
NAD
Synapses
Oxidation-Reduction
Neurotransmitter Agents
Parkinson Disease
Psychiatry
Reactive Oxygen Species
Alzheimer Disease
Homeostasis
Stem Cells
Adenosine Triphosphate
Stroke
Lipids
Neurons
Growth

Keywords

  • Mitochondria biogenesis
  • Mitochondria fission and fusion
  • Neural progenitor cell

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Cheng, A., Hou, Y., & Mattson, M. P. (2010). Mitochondria and neuroplasticity. ASN Neuro, 2(5), 243-256. [e00045]. https://doi.org/10.1042/AN20100019

Mitochondria and neuroplasticity. / Cheng, Aiwu; Hou, Yan; Mattson, Mark P.

In: ASN Neuro, Vol. 2, No. 5, e00045, 2010, p. 243-256.

Research output: Contribution to journalArticle

Cheng, A, Hou, Y & Mattson, MP 2010, 'Mitochondria and neuroplasticity', ASN Neuro, vol. 2, no. 5, e00045, pp. 243-256. https://doi.org/10.1042/AN20100019
Cheng A, Hou Y, Mattson MP. Mitochondria and neuroplasticity. ASN Neuro. 2010;2(5):243-256. e00045. https://doi.org/10.1042/AN20100019
Cheng, Aiwu ; Hou, Yan ; Mattson, Mark P. / Mitochondria and neuroplasticity. In: ASN Neuro. 2010 ; Vol. 2, No. 5. pp. 243-256.
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