Mitochondria: A new target for K+ channel openers

Adam Szewczyk, Eduardo Marbán

Research output: Contribution to journalArticle


Potassium channel openers have diverse actions ranging from vasodilation to promotion of hair growth. These drugs can also render the heart, and most likely other tissues, resistant to ischaemic necrosis, raising the possibility that they might prove useful in myocardial infarction and stroke. New research points to mitochondrial ATP-dependent K+ channels, not their classical surface membrane counterparts, as the likely effectors of the cardioprotective effects of K+ channel openers. Here, the evidence implicating mitochondrial channels and the prospects for novel drug development are reviewed.

Original languageEnglish (US)
Pages (from-to)157-161
Number of pages5
JournalTrends in Pharmacological Sciences
Issue number4
StatePublished - Apr 1 1999

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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