Mitochondria: A new target for K+ channel openers

Adam Szewczyk, Eduardo Marbán

Research output: Contribution to journalArticle

Abstract

Potassium channel openers have diverse actions ranging from vasodilation to promotion of hair growth. These drugs can also render the heart, and most likely other tissues, resistant to ischaemic necrosis, raising the possibility that they might prove useful in myocardial infarction and stroke. New research points to mitochondrial ATP-dependent K+ channels, not their classical surface membrane counterparts, as the likely effectors of the cardioprotective effects of K+ channel openers. Here, the evidence implicating mitochondrial channels and the prospects for novel drug development are reviewed.

Original languageEnglish (US)
Pages (from-to)157-161
Number of pages5
JournalTrends in Pharmacological Sciences
Volume20
Issue number4
DOIs
StatePublished - Apr 1 1999

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Mitochondria
Potassium Channels
Vasodilation
Pharmaceutical Preparations
Necrosis
Adenosine Triphosphate
Stroke
Myocardial Infarction
Tissue
Membranes
Growth
Research
mitochondrial K(ATP) channel

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Mitochondria : A new target for K+ channel openers. / Szewczyk, Adam; Marbán, Eduardo.

In: Trends in Pharmacological Sciences, Vol. 20, No. 4, 01.04.1999, p. 157-161.

Research output: Contribution to journalArticle

Szewczyk, Adam ; Marbán, Eduardo. / Mitochondria : A new target for K+ channel openers. In: Trends in Pharmacological Sciences. 1999 ; Vol. 20, No. 4. pp. 157-161.
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