TY - JOUR
T1 - Mismatched related and unrelated donors for allogeneic hematopoietic cell transplantation for adults with hematologic malignancies
AU - Eapen, Mary
AU - O'Donnell, Paul
AU - Brunstein, Claudio G.
AU - Wu, Juan
AU - Barowski, Kate
AU - Mendizabal, Adam
AU - Fuchs, Ephraim J.
N1 - Publisher Copyright:
© 2014 American Society for Blood and Marrow Transplantation.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Two parallel phase II trials in adults with hematologic malignancies demonstrated comparable survival after reduced-intensity conditioning and transplantation of either 2 HLA-mismatched umbilical cord blood (UCB) units or bone marrow from HLA-haploidentical relatives. Donor choice is often subject to physician practice and institutional preference. Despite clear preliminary evidence of equipoise between HLA-haploidentical related donor and double unrelated donor UCB transplantation, the actual prospect of being randomized between these 2 very different donor sources is daunting to patients and their treating physicians alike. Under these circumstances, it is challenging to conduct a phase III randomized trial in which patients are assigned to the UCB or haploidentical bone marrow arms. Therefore, we aimed to provide an evidence-based review and recommendations for selecting donors for adults without an HLA-matched sibling or an HLA-matched adult unrelated donor.
AB - Two parallel phase II trials in adults with hematologic malignancies demonstrated comparable survival after reduced-intensity conditioning and transplantation of either 2 HLA-mismatched umbilical cord blood (UCB) units or bone marrow from HLA-haploidentical relatives. Donor choice is often subject to physician practice and institutional preference. Despite clear preliminary evidence of equipoise between HLA-haploidentical related donor and double unrelated donor UCB transplantation, the actual prospect of being randomized between these 2 very different donor sources is daunting to patients and their treating physicians alike. Under these circumstances, it is challenging to conduct a phase III randomized trial in which patients are assigned to the UCB or haploidentical bone marrow arms. Therefore, we aimed to provide an evidence-based review and recommendations for selecting donors for adults without an HLA-matched sibling or an HLA-matched adult unrelated donor.
KW - Alternative donor transplantation
KW - Donor selection algorithm
KW - Hematologic malignancy
UR - http://www.scopus.com/inward/record.url?scp=84912522258&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84912522258&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2014.05.015
DO - 10.1016/j.bbmt.2014.05.015
M3 - Review article
C2 - 24862638
AN - SCOPUS:84912522258
SN - 1083-8791
VL - 20
SP - 1485
EP - 1492
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 10
ER -