TY - JOUR
T1 - Mismatched HL-A haplotypes with antigens HL-A1, 3, and 11 associated with excellent renal allograft function
AU - Braun, W. E.
AU - Straffon, R. A.
AU - Nakamoto, S.
AU - Popowniak, K. L.
AU - Gifford, R. W.
AU - Kuruvila, C.
AU - Zachary, A. A.
PY - 1973/1
Y1 - 1973/1
N2 - In a no-exclusion study of 76 genotyped recipients of living related allografts, 51 received definitely mismatched haplotypes. Those mismatched haplotypes carrying the cross reacting antigens HL-A1,3, or 11 were associated with a significantly increased incidence of excellent functioning allografts—19—and only a single failure (P < 0.001). In those patients with a mismatched haplotype without HL-A1,3, or 11, allograft failures—13—exceeded excellent functioning allografts—11. Also evaluated were the possible roles of other donor cross reacting groups, donor-recipient cross reacting antigens, specific recipient antigens such as HL-A1, lymphocytotoxic, antinuclear, and anti- glomerular basement membrane antibodies (anti-GBM), the inflammatory response and delayed hypersensitivity (DH) to dinitrochlorobenzene (DNCB), preexisting DH, and the response of recipient lymphocytes to phytohemagglutinin.
AB - In a no-exclusion study of 76 genotyped recipients of living related allografts, 51 received definitely mismatched haplotypes. Those mismatched haplotypes carrying the cross reacting antigens HL-A1,3, or 11 were associated with a significantly increased incidence of excellent functioning allografts—19—and only a single failure (P < 0.001). In those patients with a mismatched haplotype without HL-A1,3, or 11, allograft failures—13—exceeded excellent functioning allografts—11. Also evaluated were the possible roles of other donor cross reacting groups, donor-recipient cross reacting antigens, specific recipient antigens such as HL-A1, lymphocytotoxic, antinuclear, and anti- glomerular basement membrane antibodies (anti-GBM), the inflammatory response and delayed hypersensitivity (DH) to dinitrochlorobenzene (DNCB), preexisting DH, and the response of recipient lymphocytes to phytohemagglutinin.
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U2 - 10.1097/00007890-197301000-00013
DO - 10.1097/00007890-197301000-00013
M3 - Article
C2 - 4575924
AN - SCOPUS:0015549183
SN - 0041-1337
VL - 15
SP - 86
EP - 91
JO - Transplantation
JF - Transplantation
IS - 1
ER -