miRNAs and SAMHD1 regulation in vitro and in a model of HIV CNS disease

Kenneth W. Witwer, Erin L. Buchanan, Stephanie L. Myers, Melissa A. McAlexander

Research output: Contribution to journalLetter

Abstract

Pilakka-Kanthikeel et al. recently reported higher levels of the retroviral restriction factor sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) in astrocytes than in microglia, suggesting that SAMHD1 levels might explain in part the relatively refractory nature of astrocytes to retroviral replication. These findings are consistent with our studies of simian and human immunodeficiency virus infection of astrocytes and macrophages. Similarly, a role for two host microRNAs in post-transcriptional regulation of SAMHD1 agrees with our in vitro results and those of others. However, data from an animal model of HIV neurologic disorders may not be consistent with robust miRNA-mediated regulation of SAMHD1 in vivo.

Original languageEnglish (US)
Article number159
JournalJournal of Neuroinflammation
Volume12
Issue number1
DOIs
StatePublished - Sep 4 2015

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Neurology
  • Cellular and Molecular Neuroscience

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