miRNA and cholesterol homeostasis

Tae Il Jeon; Timothy F. Osborne

doi:10.1016/j.bbalip.2016.01.005

miRNA and cholesterol homeostasis

Tae Il Jeon, Timothy F. Osborne

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

MicroRNAs (miRNAs) have recently emerged as a novel class of epigenetic regulators of gene expression. They are systemically involved in the control of lipid metabolism through a complex interactive mechanism that involves gene regulatory networks. Hence, they can contribute to defective lipid metabolism and metabolic diseases. Here, we review recent advances in the roles of lipid-sensing transcription factors in regulating miRNA gene networks, as well as miRNA expression and function in the regulation of cholesterol metabolism.

Original language	English (US)
Pages (from-to)	2041-2046
Number of pages	6
Journal	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume	1861
Issue number	12
DOIs	https://doi.org/10.1016/j.bbalip.2016.01.005
State	Published - Dec 1 2016
Externally published	Yes

Keywords

Cholesterol metabolism
Metabolic disease
MicroRNA
Transcription factor

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.bbalip.2016.01.005

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title = "miRNA and cholesterol homeostasis",

abstract = "MicroRNAs (miRNAs) have recently emerged as a novel class of epigenetic regulators of gene expression. They are systemically involved in the control of lipid metabolism through a complex interactive mechanism that involves gene regulatory networks. Hence, they can contribute to defective lipid metabolism and metabolic diseases. Here, we review recent advances in the roles of lipid-sensing transcription factors in regulating miRNA gene networks, as well as miRNA expression and function in the regulation of cholesterol metabolism.",

keywords = "Cholesterol metabolism, Metabolic disease, MicroRNA, Transcription factor",

author = "Jeon, {Tae Il} and Osborne, {Timothy F.}",

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AU - Jeon, Tae Il

AU - Osborne, Timothy F.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - MicroRNAs (miRNAs) have recently emerged as a novel class of epigenetic regulators of gene expression. They are systemically involved in the control of lipid metabolism through a complex interactive mechanism that involves gene regulatory networks. Hence, they can contribute to defective lipid metabolism and metabolic diseases. Here, we review recent advances in the roles of lipid-sensing transcription factors in regulating miRNA gene networks, as well as miRNA expression and function in the regulation of cholesterol metabolism.

AB - MicroRNAs (miRNAs) have recently emerged as a novel class of epigenetic regulators of gene expression. They are systemically involved in the control of lipid metabolism through a complex interactive mechanism that involves gene regulatory networks. Hence, they can contribute to defective lipid metabolism and metabolic diseases. Here, we review recent advances in the roles of lipid-sensing transcription factors in regulating miRNA gene networks, as well as miRNA expression and function in the regulation of cholesterol metabolism.

KW - Cholesterol metabolism

KW - Metabolic disease

KW - MicroRNA

KW - Transcription factor

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DO - 10.1016/j.bbalip.2016.01.005

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AN - SCOPUS:84956621960

SN - 1388-1981

VL - 1861

SP - 2041

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JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

IS - 12

ER -

miRNA and cholesterol homeostasis

Abstract

Keywords

ASJC Scopus subject areas

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