MIRD pamphlet no. 23: Quantitative SPECT for patient-specific 3-dimensional dosimetry in internal radionuclide therapy

Yuni K. Dewaraja, Eric C. Frey, George Sgouros, A. Bertrand Brill, Peter Roberson, Pat B. Zanzonico, Michael Ljungberg

Research output: Contribution to journalReview article


In internal radionuclide therapy, a growing interest in voxel-level estimates of tissue-absorbed dose has been driven by the desire to report radiobiologic quantities that account for the biologic consequences of both spatial and temporal nonuniformities in these dose estimates. This report presents an overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regional and voxel levels. Combined SPECT/CT image-based methods are emphasized, because the CT-derived anatomic information allows one to address multiple technical factors that affect SPECT quantification while facilitating the patient-specific voxel-level dosimetry calculation itself. SPECT imaging and reconstruction techniques for quantification in radionuclide therapy are not necessarily the same as those designed to optimize diagnostic imaging quality. The current overview is intended as an introduction to an upcoming series of MIRD pamphlets with detailed radionuclide-specific recommendations intended to provide best-practice SPECT quantification-based guidance for radionuclide dosimetry.

Original languageEnglish (US)
Pages (from-to)1310-1325
Number of pages16
JournalJournal of Nuclear Medicine
Issue number8
StatePublished - Aug 1 2012



  • 3D dosimetry
  • Absorbed dose
  • MIRD
  • Patient-specific dosimetry
  • Quantitative SPECT
  • Radionuclide therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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