MIRD pamphlet No. 22 (Abridged): Radiobiology and dosimetry of α-particle emitters for targeted radionuclide therapy

George Sgouros; John C. Roeske; Michael R. McDevitt; Stig Palm; Barry J. Allen; Darrell R. Fisher; A. Bertrand Brill; Hong Song; Roger W. Howell; Gamal Akabani; Wesley E. Bolch; Ruby F. Meredith; Barry W. Wessels; Pat B. Zanzonico

doi:10.2967/jnumed.108.058651

MIRD pamphlet No. 22 (Abridged): Radiobiology and dosimetry of α-particle emitters for targeted radionuclide therapy

George Sgouros, John C. Roeske, Michael R. McDevitt, Stig Palm, Barry J. Allen, Darrell R. Fisher, A. Bertrand Brill, Hong Song, Roger W. Howell, Gamal Akabani, Wesley E. Bolch, Ruby F. Meredith, Barry W. Wessels, Pat B. Zanzonico

School of Medicine

Research output: Contribution to journal › Review article › peer-review

220 Scopus citations

Abstract

The potential of α-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of α-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with α-particle emitters. Although α-emitters have been studied for many decades, their current use in humans for targeted therapy is an important milestone. The objective of this work is to review those aspects of the field that are pertinent to targeted α-particle emitter therapy and to provide guidance and recommendations for human α-particle emitter dosimetry.

Original language	English (US)
Pages (from-to)	311-328
Number of pages	18
Journal	Journal of Nuclear Medicine
Volume	51
Issue number	2
DOIs	https://doi.org/10.2967/jnumed.108.058651
State	Published - Feb 1 2010

Keywords

Human α-particle emitter dosimetry
Targeted α-particle emitter therapy
α-particle emitters

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.2967/jnumed.108.058651

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Sgouros, G., Roeske, J. C., McDevitt, M. R., Palm, S., Allen, B. J., Fisher, D. R., Brill, A. B., Song, H., Howell, R. W., Akabani, G., Bolch, W. E., Meredith, R. F., Wessels, B. W., & Zanzonico, P. B. (2010). MIRD pamphlet No. 22 (Abridged): Radiobiology and dosimetry of α-particle emitters for targeted radionuclide therapy. Journal of Nuclear Medicine, 51(2), 311-328. https://doi.org/10.2967/jnumed.108.058651

Sgouros, G, Roeske, JC, McDevitt, MR, Palm, S, Allen, BJ, Fisher, DR, Brill, AB, Song, H, Howell, RW, Akabani, G, Bolch, WE, Meredith, RF, Wessels, BW & Zanzonico, PB 2010, 'MIRD pamphlet No. 22 (Abridged): Radiobiology and dosimetry of α-particle emitters for targeted radionuclide therapy', Journal of Nuclear Medicine, vol. 51, no. 2, pp. 311-328. https://doi.org/10.2967/jnumed.108.058651

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abstract = "The potential of α-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of α-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with α-particle emitters. Although α-emitters have been studied for many decades, their current use in humans for targeted therapy is an important milestone. The objective of this work is to review those aspects of the field that are pertinent to targeted α-particle emitter therapy and to provide guidance and recommendations for human α-particle emitter dosimetry.",

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MIRD pamphlet No. 22 (Abridged): Radiobiology and dosimetry of α-particle emitters for targeted radionuclide therapy

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