Mir-210: A therapeutic target in cancer

Liu Hong, Yu Han, Hongwei Zhang, Qingchuan Zhao, Yuan Qiao

Research output: Contribution to journalReview article

Abstract

Introduction: As the predominant miRNA regulated by hypoxia, miR-210 correlates with survival in cancer patients. miR-210 may play important roles in regulation of cell growth, angiogenesis and apoptosis in different human tumor models, indicating that it can be used as a therapeutic target. Areas covered: This review covers all literature related to miR-210 in malignant tumors from the past 5 years, and analyzes the biological functions and molecular mechanisms of it. The authors also envisage future developments toward the clinical applications of miR-210 to cancer diagnosis and treatment. Expert opinion: miR-210 may function as a new therapeutic target for anticancer intervention. Considering that the exact function of miR-210 is still not well characterized and understood, more investigations should be performed to promote the success of therapeutic clinical use of miR-210 in cancer.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalExpert opinion on therapeutic targets
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2013

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Keywords

  • Angiogenesis
  • Apoptosis
  • Human cancers
  • Hypoxia
  • MiR-210
  • MicroRNA
  • Survival
  • cell cycle

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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