Minocycline in the chemotherapy of murine toxoplasmosis

K. F. Tabbara, S. Sakuragi, G. R. O'Connor

Research output: Contribution to journalArticle

Abstract

The effects of minocycline alone or in combination with sulphadiazine were evaluated against acute murine toxoplasmosis and compared with the efficacy of pyrimethamine and sulphadiazine. The data presented show that mice could be protected from acute toxoplasmosis by minocycline, in spite of using a virulent strain of Toxoplasma gondii, a large inoculum, and a delay in the administration of the drug. Acute toxoplasmic infection in mice could be eradicated by a minocycline-sulphadiazine combination, which was found to be as effective as pyrimethamine-sulphadiazine combination therapy.

Original languageEnglish (US)
Pages (from-to)297-302
Number of pages6
JournalParasitology
Volume84
Issue number2
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Parasitology

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    Tabbara, K. F., Sakuragi, S., & O'Connor, G. R. (1982). Minocycline in the chemotherapy of murine toxoplasmosis. Parasitology, 84(2), 297-302.