Minocycline in experimental ocular toxoplasmosis in the rabbit

D. F. Rollins, K. F. Tabbara, R. Ghosheh, R. A. Nozik

Research output: Contribution to journalArticle

Abstract

We studied the effects of minocycline, a semisynthetic tetracycline, on experimentally induced toxoplasmic retinochoroiditis in the rabbit. In two experiments we found that this drug effectively ameliorated the clinical disease and sterilized the ocular tissues from Toxoplasma organisms. Minocycline prevented death from toxoplasmic encephalitis in 75% of the animals, whereas all the control animals died of toxoplasmic encephalitis. Minocycline appears to be a promising agent for ocular toxoplasmosis.

Original languageEnglish (US)
Pages (from-to)361-365
Number of pages5
JournalAmerican Journal of Ophthalmology
Volume93
Issue number3
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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  • Cite this

    Rollins, D. F., Tabbara, K. F., Ghosheh, R., & Nozik, R. A. (1982). Minocycline in experimental ocular toxoplasmosis in the rabbit. American Journal of Ophthalmology, 93(3), 361-365.