Minocycline in experimental ocular toxoplasmosis in the rabbit

D. F. Rollins, K. F. Tabbara, R. Ghosheh, R. A. Nozik

Research output: Contribution to journalArticle

Abstract

We studied the effects of minocycline, a semisynthetic tetracycline, on experimentally induced toxoplasmic retinochoroiditis in the rabbit. In two experiments we found that this drug effectively ameliorated the clinical disease and sterilized the ocular tissues from Toxoplasma organisms. Minocycline prevented death from toxoplasmic encephalitis in 75% of the animals, whereas all the control animals died of toxoplasmic encephalitis. Minocycline appears to be a promising agent for ocular toxoplasmosis.

Original languageEnglish (US)
Pages (from-to)361-365
Number of pages5
JournalAmerican Journal of Ophthalmology
Volume93
Issue number3
StatePublished - 1982
Externally publishedYes

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Ocular Toxoplasmosis
Minocycline
Encephalitis
Rabbits
Toxoplasma
Tetracycline
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Rollins, D. F., Tabbara, K. F., Ghosheh, R., & Nozik, R. A. (1982). Minocycline in experimental ocular toxoplasmosis in the rabbit. American Journal of Ophthalmology, 93(3), 361-365.

Minocycline in experimental ocular toxoplasmosis in the rabbit. / Rollins, D. F.; Tabbara, K. F.; Ghosheh, R.; Nozik, R. A.

In: American Journal of Ophthalmology, Vol. 93, No. 3, 1982, p. 361-365.

Research output: Contribution to journalArticle

Rollins, DF, Tabbara, KF, Ghosheh, R & Nozik, RA 1982, 'Minocycline in experimental ocular toxoplasmosis in the rabbit', American Journal of Ophthalmology, vol. 93, no. 3, pp. 361-365.
Rollins DF, Tabbara KF, Ghosheh R, Nozik RA. Minocycline in experimental ocular toxoplasmosis in the rabbit. American Journal of Ophthalmology. 1982;93(3):361-365.
Rollins, D. F. ; Tabbara, K. F. ; Ghosheh, R. ; Nozik, R. A. / Minocycline in experimental ocular toxoplasmosis in the rabbit. In: American Journal of Ophthalmology. 1982 ; Vol. 93, No. 3. pp. 361-365.
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