Minocycline effects in patients with active trachoma

Khalid F. Tabbara, Paula Summanen, Peter B. Taylor, Eileen M. Burd, Othman Al Omar

Research output: Contribution to journalArticle

Abstract

Minocycline has a unique solubility in lipids and may reach therapeutic concentrations in tears and saliva. In two consecutive prospective double-masked clinical trials that were carried out in two villages in Saudi Arabia, we assessed the effects of oral minocycline in the treatment of trachoma and compared its effects with those of topical tetracycline ointment in the first study and to tetracycline ointment and placebo in the second study. A total of 178 eyes in 96 patients were included. The age range was 7 to 14 years, with a mean age of 9 years. All patients underwent complete ophthalmologic evaluation. School children were divided into two groups in a double-masked fashion. The first group received either oral minocycline or topical tetracycline 1% ointment and the second group was divided into three subgroups, each receiving one of the following therapeutic modalities: oral minocycline, topical tetracycline ointment, or placebo ointment. All patients were evaluated before initiation of therapy, at three weeks and at 12 months following treatment. Therapy was continued for a period of five weeks. These two double-masked field-based clinical trials have shown both minocycline given orally and tetracycline ointment given topically were effective in decreasing the intensity of inflammation due to trachoma. Oral minocycline was found to be equally effective as topical tetracycline ointment in the treatment of trachoma at three weeks. Minocycline, however, was found to be superior to topical tetracycline when patients were evaluated one year after therapy (p

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalInternational Ophthalmology
Volume12
Issue number1
DOIs
StatePublished - Mar 1988
Externally publishedYes

Fingerprint

Trachoma
Minocycline
Ointments
Tetracycline
Therapeutics
Placebos
Clinical Trials
Saudi Arabia
Tears
Saliva
Solubility
Inflammation
Lipids

Keywords

  • Chlamydia trachomatis
  • minocycline
  • tetracycline
  • trachoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Tabbara, K. F., Summanen, P., Taylor, P. B., Burd, E. M., & Omar, O. A. (1988). Minocycline effects in patients with active trachoma. International Ophthalmology, 12(1), 59-63. https://doi.org/10.1007/BF00133783

Minocycline effects in patients with active trachoma. / Tabbara, Khalid F.; Summanen, Paula; Taylor, Peter B.; Burd, Eileen M.; Omar, Othman Al.

In: International Ophthalmology, Vol. 12, No. 1, 03.1988, p. 59-63.

Research output: Contribution to journalArticle

Tabbara, KF, Summanen, P, Taylor, PB, Burd, EM & Omar, OA 1988, 'Minocycline effects in patients with active trachoma', International Ophthalmology, vol. 12, no. 1, pp. 59-63. https://doi.org/10.1007/BF00133783
Tabbara KF, Summanen P, Taylor PB, Burd EM, Omar OA. Minocycline effects in patients with active trachoma. International Ophthalmology. 1988 Mar;12(1):59-63. https://doi.org/10.1007/BF00133783
Tabbara, Khalid F. ; Summanen, Paula ; Taylor, Peter B. ; Burd, Eileen M. ; Omar, Othman Al. / Minocycline effects in patients with active trachoma. In: International Ophthalmology. 1988 ; Vol. 12, No. 1. pp. 59-63.
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