Minisatellite mapping in manic depression

S. Hodgkinson, H. M D Gurling, R. H. Marchbanks, M. McInnis, H. Petursson

Research output: Contribution to journalArticle

Abstract

Hypervariable regions of DNA exist at many discrete loci in the human genome. Variations in the length of specific classes of hypervariable DNA termed "minisatellite" sequences may be detected by hybridisation of radioactive probes composed of a common10-15 base pair repeat or "core" sequence which is shared by each of the minisatellite loci. Such a procedure was used to perform linkage analysis on a kindred in which a disease allele causing manic depression appeared to be segregating as an autosomal dominant. Results indicate no apparent linkage between a manic depression allele and at least 20 hypervariable genetic loci which acted as markers. However, because of the hypervariability of the minisatellite loci these results do not preclude similar analyses of other manic depressive pedigrees being productive because each such family will have distinct observable minisatellite alleles at loci specific to that family. The method could be usefully applied to the genetic analysis of other psychiatric disorders where heterogeneity is suspected and where a single autosomal major gene locus appears to be responsible for causing multiple cases within a single kindred.

Original languageEnglish (US)
Pages (from-to)589-596
Number of pages8
JournalJournal of Psychiatric Research
Volume21
Issue number4
DOIs
StatePublished - 1987
Externally publishedYes

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Minisatellite Repeats
Alleles
Genetic Loci
DNA
Human Genome
Pedigree
Base Pairing
Psychiatry
Genes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Hodgkinson, S., Gurling, H. M. D., Marchbanks, R. H., McInnis, M., & Petursson, H. (1987). Minisatellite mapping in manic depression. Journal of Psychiatric Research, 21(4), 589-596. https://doi.org/10.1016/0022-3956(87)90109-9

Minisatellite mapping in manic depression. / Hodgkinson, S.; Gurling, H. M D; Marchbanks, R. H.; McInnis, M.; Petursson, H.

In: Journal of Psychiatric Research, Vol. 21, No. 4, 1987, p. 589-596.

Research output: Contribution to journalArticle

Hodgkinson, S, Gurling, HMD, Marchbanks, RH, McInnis, M & Petursson, H 1987, 'Minisatellite mapping in manic depression', Journal of Psychiatric Research, vol. 21, no. 4, pp. 589-596. https://doi.org/10.1016/0022-3956(87)90109-9
Hodgkinson S, Gurling HMD, Marchbanks RH, McInnis M, Petursson H. Minisatellite mapping in manic depression. Journal of Psychiatric Research. 1987;21(4):589-596. https://doi.org/10.1016/0022-3956(87)90109-9
Hodgkinson, S. ; Gurling, H. M D ; Marchbanks, R. H. ; McInnis, M. ; Petursson, H. / Minisatellite mapping in manic depression. In: Journal of Psychiatric Research. 1987 ; Vol. 21, No. 4. pp. 589-596.
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