Minireview: Novel Micropeptide Discovery by Proteomics and Deep Sequencing Methods

Ravi Tharakan, Akira Sawa

Research output: Contribution to journalReview articlepeer-review


A novel class of small proteins, called micropeptides, has recently been discovered in the genome. These proteins, which have been found to play important roles in many physiological and cellular systems, are shorter than 100 amino acids and were overlooked during previous genome annotations. Discovery and characterization of more micropeptides has been ongoing, often using -omics methods such as proteomics, RNA sequencing, and ribosome profiling. In this review, we survey the recent advances in the micropeptides field and describe the methodological and conceptual challenges facing future micropeptide endeavors.

Original languageEnglish (US)
Article number651485
JournalFrontiers in Genetics
StatePublished - May 6 2021


  • RNA sequencing
  • genomics
  • micropeptides
  • miniproteins
  • proteogenomics
  • proteomics
  • ribosome profiling
  • sORF

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Genetics(clinical)


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