Minireview: Gut peptides: Targets for antiobesity drug development?

Timothy H. Moran, Megan J. Dailey

Research output: Contribution to journalShort surveypeer-review

Abstract

Gut peptides play multiple roles in the controls of gastrointestinal function and in the initiation and termination of meals. Plasma levels of these peptides are differentially affected by the presence of nutrients in the digestive tract, and the patterns of peptide release are consistent with both their feeding stimulatory and inhibitory actions. A number of these peptide systems have been investigated as potential targets for antiobesity drug development. Progress has been made in developing long-acting peptide analogs and, in some cases, nonpeptide agonists and antagonists. Whether any individual approach will have significant long-term efficacy remains to be demonstrated. Approaches that target multiple systems may hold the most promise.

Original languageEnglish (US)
Pages (from-to)2526-2530
Number of pages5
JournalEndocrinology
Volume150
Issue number6
DOIs
StatePublished - Jun 2009

ASJC Scopus subject areas

  • Endocrinology

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