Minipig negative slow wave demonstrates target/nontarget differences in P300 paradigm

Sidse Marie Arnfred; Nanna Marie Lind; Anette Moustgaard; Axel Kornerup Hansen; Albert Gjedde

doi:10.1016/S1053-8119(03)00314-8

Minipig negative slow wave demonstrates target/nontarget differences in P300 paradigm

Sidse Marie Arnfred, Nanna Marie Lind, Anette Moustgaard, Axel Kornerup Hansen, Albert Gjedde

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The negative slow wave (NSW) is a late component of the event-related potential (ERP) in man modulated like the P300 by the stimulus, the task, and the response demand. Aiming at the development of a minipig model of schizophrenia, we investigated scalp ERPs in an auditory P300 paradigm in six Göttingen minipigs. Before training, we observed no difference between target and nontarget NSW. After training, target NSW amplitude was increased 50% compared to nontarget. A P350 was recognized, but the finding of a lack of target/nontarget difference is not conclusive.

Original language	English (US)
Pages (from-to)	587-590
Number of pages	4
Journal	NeuroImage
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/S1053-8119(03)00314-8
State	Published - Sep 1 2003
Externally published	Yes

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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10.1016/S1053-8119(03)00314-8

Cite this

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title = "Minipig negative slow wave demonstrates target/nontarget differences in P300 paradigm",

abstract = "The negative slow wave (NSW) is a late component of the event-related potential (ERP) in man modulated like the P300 by the stimulus, the task, and the response demand. Aiming at the development of a minipig model of schizophrenia, we investigated scalp ERPs in an auditory P300 paradigm in six G{\"o}ttingen minipigs. Before training, we observed no difference between target and nontarget NSW. After training, target NSW amplitude was increased 50% compared to nontarget. A P350 was recognized, but the finding of a lack of target/nontarget difference is not conclusive.",

author = "Arnfred, {Sidse Marie} and Lind, {Nanna Marie} and Anette Moustgaard and Hansen, {Axel Kornerup} and Albert Gjedde",

note = "Funding Information: The study was supported by unrestricted grants from the Lundbeck Foundation, the Novo Nordic Research Foundation, The H:S Research Foundation, and a Ph.D. grant for the second author by the Faculty of Health Sciences, University of Copenhagen. We greatly appreciate the hardware and digital control systems built by S. Christoffersen, Department of Medical Physiology, University of Copenhagen",

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AU - Arnfred, Sidse Marie

AU - Lind, Nanna Marie

AU - Moustgaard, Anette

AU - Hansen, Axel Kornerup

AU - Gjedde, Albert

N1 - Funding Information: The study was supported by unrestricted grants from the Lundbeck Foundation, the Novo Nordic Research Foundation, The H:S Research Foundation, and a Ph.D. grant for the second author by the Faculty of Health Sciences, University of Copenhagen. We greatly appreciate the hardware and digital control systems built by S. Christoffersen, Department of Medical Physiology, University of Copenhagen

PY - 2003/9/1

Y1 - 2003/9/1

N2 - The negative slow wave (NSW) is a late component of the event-related potential (ERP) in man modulated like the P300 by the stimulus, the task, and the response demand. Aiming at the development of a minipig model of schizophrenia, we investigated scalp ERPs in an auditory P300 paradigm in six Göttingen minipigs. Before training, we observed no difference between target and nontarget NSW. After training, target NSW amplitude was increased 50% compared to nontarget. A P350 was recognized, but the finding of a lack of target/nontarget difference is not conclusive.

AB - The negative slow wave (NSW) is a late component of the event-related potential (ERP) in man modulated like the P300 by the stimulus, the task, and the response demand. Aiming at the development of a minipig model of schizophrenia, we investigated scalp ERPs in an auditory P300 paradigm in six Göttingen minipigs. Before training, we observed no difference between target and nontarget NSW. After training, target NSW amplitude was increased 50% compared to nontarget. A P350 was recognized, but the finding of a lack of target/nontarget difference is not conclusive.

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Minipig negative slow wave demonstrates target/nontarget differences in P300 paradigm

Abstract

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