Mining the B Cell Repertoire for Broadly Neutralizing Monoclonal Antibodies to HIV-1

Peter D. Kwong; John R. Mascola; Gary J. Nabel

doi:10.1016/j.chom.2009.09.008

Mining the B Cell Repertoire for Broadly Neutralizing Monoclonal Antibodies to HIV-1

Peter D. Kwong, John R. Mascola, Gary J. Nabel

Research output: Contribution to journal › Article › peer-review

Abstract

Monoclonal antibodies that effectively neutralize HIV-1 have been widely sought, yet few have been isolated. Now, technological advances in sera evaluation, B cell stimulation, microneutralization, and antibody cloning have allowed Burton and colleagues to identify two broadly neutralizing monoclonal antibodies, PG9 and PG16, which provide insights for HIV vaccine design.

Original language	English (US)
Pages (from-to)	292-294
Number of pages	3
Journal	Cell Host and Microbe
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2009.09.008
State	Published - Nov 22 2009
Externally published	Yes

ASJC Scopus subject areas

Immunology and Microbiology(all)
Cancer Research
Molecular Biology

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10.1016/j.chom.2009.09.008

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title = "Mining the B Cell Repertoire for Broadly Neutralizing Monoclonal Antibodies to HIV-1",

abstract = "Monoclonal antibodies that effectively neutralize HIV-1 have been widely sought, yet few have been isolated. Now, technological advances in sera evaluation, B cell stimulation, microneutralization, and antibody cloning have allowed Burton and colleagues to identify two broadly neutralizing monoclonal antibodies, PG9 and PG16, which provide insights for HIV vaccine design.",

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