Mining the B Cell Repertoire for Broadly Neutralizing Monoclonal Antibodies to HIV-1

Peter D. Kwong, John R. Mascola, Gary J. Nabel

Research output: Contribution to journalArticlepeer-review

Abstract

Monoclonal antibodies that effectively neutralize HIV-1 have been widely sought, yet few have been isolated. Now, technological advances in sera evaluation, B cell stimulation, microneutralization, and antibody cloning have allowed Burton and colleagues to identify two broadly neutralizing monoclonal antibodies, PG9 and PG16, which provide insights for HIV vaccine design.

Original languageEnglish (US)
Pages (from-to)292-294
Number of pages3
JournalCell Host and Microbe
Volume6
Issue number4
DOIs
StatePublished - Nov 22 2009
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Cancer Research
  • Molecular Biology

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