@inproceedings{77a7953d79ca4e3482692144dbad2d5f,
title = "Mining severe drug-drug interaction adverse events using semantic web technologies: A case study",
abstract = "Drug-drug interactions (DDIs) are a major contributing factor for unexpected adverse drug events (ADEs). However, few of knowledge resources cover the severity information of ADEs that is critical for prioritizing the medical need. The objective of the study is to develop and evaluate a Semantic Web-based approach for mining severe DDI-induced ADEs. We utilized a normalized FDA Adverse Event Report System (AERS) dataset and performed a case study of three frequently prescribed cardiovascular drugs: Warfarin, Clopidogrel and Simvastatin. We extracted putative DDI-ADE pairs and their associated outcome codes. We developed a pipeline to validate the associations using ADE datasets from SIDER and PharmGKB. We also performed a cross validation using electronic medical records (EMR) data. We leveraged the Common Terminology Criteria for Adverse Event (CTCAE) grading system and classified the DDI-induced ADEs into the CTCAE in the Web Ontology Language (OWL). We identified and validated 601 DDI-ADE pairs for the three drugs using the validation pipeline, of which 61 pairs are in Grade 5, 56 pairs in Grade 4 and 484 pairs in Grade 3. Among 601 pairs, the signals of 59 DDI-ADE pairs were identified from the EMR data. The approach developed could be generalized to detect the signals of putative severe ADEs induced by DDIs in other drug domains and would be useful for supporting translational and pharmacovigilance study of severe ADEs.",
keywords = "Adverse drug events, Adverse event report system (AERS), Drug-drug interaction, Semantic web technologies, Severity",
author = "Guoqian Jiang and Hongfang Liu and Solbrig, {Harold R.} and Chute, {Christopher G.}",
note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2014.; International Workshops on Data Mining and Decision Analytics for Public Health, Biologically Inspired Data Mining Techniques, Mobile Data Management, Mining, and Computing on Social Networks, Big Data Science and Engineering on E-Commerce, Cloud Service Discovery, MSMV-MBI, Scalable Dats Analytics, Data Mining and Decision Analytics for Public Health and Wellness, Algorithms for Large-Scale Information Processing in Knowledge Discovery, Data Mining in Social Networks, Data Mining in Biomedical informatics and Healthcare, Pattern Mining and Application of Big Data in conjunction with 18th Pacific-Asia Conference on Knowledge Discovery and Data Mining, PAKDD 2014 ; Conference date: 13-05-2014 Through 16-05-2014",
year = "2014",
doi = "10.1007/978-3-319-13186-3_56",
language = "English (US)",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Verlag",
pages = "628--638",
editor = "Wen-Chih Peng and Haixun Wang and Zhi-Hua Zhou and Ho, {Tu Bao} and Tseng, {Vincent S.} and Chen, {Arbee L.P.} and James Bailey",
booktitle = "Trends and Applications in Knowledge Discovery and Data Mining - PAKDD 2014 International Workshops",
}