Minimizing lipid signal bleed in brain 1H chemical shift imaging by post-acquisition grid shifting

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Purpose Low spatial resolution in conventional 1H brain chemical shifting imaging (CSI) studies causes partial volume error (PVE) or signal "bleed" that is especially deleterious to voxels near the scalp. The standard spatial apodization approach adversely affects spatial resolution. Here, a novel automated post-processing strategy of partial volume correction employing grid shifting ("PANGS") is presented, which minimizes residual PVE without compromising spatial resolution. Methods PANGS shifts the locations of the reconstruction coordinates in a designated region of image space - the scalp, to match the tissue "centers-of-mass" instead of the geometric centers of each voxel, by iteratively minimizing the PVE from the scalp into outside voxels. PANGS' performance was evaluated by numerical simulation, and in 3 Tesla 1H CSI human studies employing outer volume suppression and long echo times. Results PANGS reduced lipid contamination of cortical spectra by up to 86% (54% on average). Metabolite maps exhibited significantly less lipid artifact than conventional and spatially-filtered CSI. All methods generated quantitatively identical spectral peak areas from central brain locations, but spatial filtering increased spectral linewidths and reduced spatial resolution. Conclusion PANGS significantly reduces lipid artifacts in 1H brain CSI spectra and metabolite maps, and improves metabolite detection in cortical regions without compromising resolution. Magn Reson Med 74:320-329, 2015.

Original languageEnglish (US)
Pages (from-to)320-329
Number of pages10
JournalMagnetic resonance in medicine
Issue number2
StatePublished - Aug 1 2015


  • CSI
  • MRS
  • brain
  • lipid bleed
  • metabolite quantification
  • partial volume error
  • postprocessing

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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