TY - JOUR
T1 - Minimally modified low density lipoproteins induce aortic smooth muscle cell proliferation via the activation of mitogen activated protein kinase
AU - Balagopalakrishna, Chavali
AU - Bhunia, Anil K.
AU - Rifkind, Joseph M.
AU - Chatterjee, Subroto
PY - 1997/5/12
Y1 - 1997/5/12
N2 - We have investigated the effects of modifying LDL by Cu++ and various hemoglobin preparations on aortic smooth muscle cell proliferation and on the activation of mitogen activated protein kinase. We found that at very low concentrations ( 10 μg/ml), LDL modified by all of the above agonists markedly stimulated cell proliferation (5-10 fold). This was accompanied by a 2-3 fold stimulation in mitogen activated protein kinase (MAPK) activity. We conclude that modification of LDL under situations that are closer to those found in vivo (i.e. hypoxic conditions), may involve the activation of MAPK as a common biochemical mechanism of action. This in turn, contributes to aortic smooth muscle cell proliferation.
AB - We have investigated the effects of modifying LDL by Cu++ and various hemoglobin preparations on aortic smooth muscle cell proliferation and on the activation of mitogen activated protein kinase. We found that at very low concentrations ( 10 μg/ml), LDL modified by all of the above agonists markedly stimulated cell proliferation (5-10 fold). This was accompanied by a 2-3 fold stimulation in mitogen activated protein kinase (MAPK) activity. We conclude that modification of LDL under situations that are closer to those found in vivo (i.e. hypoxic conditions), may involve the activation of MAPK as a common biochemical mechanism of action. This in turn, contributes to aortic smooth muscle cell proliferation.
KW - Aortic smooth muscle cells
KW - Cell proliferation
KW - Mitogen activated protein kinase
KW - Modified low density lipoproteins
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U2 - 10.1023/A:1006840927835
DO - 10.1023/A:1006840927835
M3 - Article
C2 - 9144321
AN - SCOPUS:0030932753
SN - 0300-8177
VL - 170
SP - 85
EP - 89
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
IS - 1-2
ER -