Minimally modified low density lipoproteins induce aortic smooth muscle cell proliferation via the activation of mitogen activated protein kinase

Chavali Balagopalakrishna, Anil K. Bhunia, Joseph M. Rifkind, Subroto Chatterjee

Research output: Contribution to journalArticle

Abstract

We have investigated the effects of modifying LDL by Cu++ and various hemoglobin preparations on aortic smooth muscle cell proliferation and on the activation of mitogen activated protein kinase. We found that at very low concentrations ( 10 μg/ml), LDL modified by all of the above agonists markedly stimulated cell proliferation (5-10 fold). This was accompanied by a 2-3 fold stimulation in mitogen activated protein kinase (MAPK) activity. We conclude that modification of LDL under situations that are closer to those found in vivo (i.e. hypoxic conditions), may involve the activation of MAPK as a common biochemical mechanism of action. This in turn, contributes to aortic smooth muscle cell proliferation.

Original languageEnglish (US)
Pages (from-to)85-89
Number of pages5
JournalMolecular and Cellular Biochemistry
Volume170
Issue number1-2
DOIs
StatePublished - May 12 1997

Keywords

  • Aortic smooth muscle cells
  • Cell proliferation
  • Mitogen activated protein kinase
  • Modified low density lipoproteins

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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