TY - JOUR
T1 - Minimally Invasive Resection of Choledochal Cyst
T2 - a Feasible and Safe Surgical Option
AU - Margonis, Georgios Antonios
AU - Spolverato, Gaya
AU - Kim, Yuhree
AU - Marques, Hugo
AU - Poultsides, George
AU - Maithel, Shishir
AU - Aldrighetti, Luca
AU - Bauer, Todd W.
AU - Jabbour, Nicolas
AU - Gamblin, T. Clark
AU - Soares, Kevin
AU - Pawlik, Timothy M.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Background: The use of minimally invasive surgery (MIS) for choledochal cyst (CC) has not been well documented. We sought to define the overall utilization and outcomes associated with the use of the open versus MIS approach for CC. We examined the factors associated with receipt of MIS for CC, as well as characterized perioperative and long-term outcomes following open versus MIS for CC. Methods: Between 1972 and 2014, a total of 368 patients who underwent resection for CC were identified from an international, multicenter database. A 2:1 propensity score matching was used to create comparable cohorts of patients to assess the effect of MIS on short-term outcomes. Results: Three hundred thirty-two patients had an open procedure, whereas 36 patients underwent an MIS approach. Children were more likely to be treated with a MIS approach (children, 24.0 % vs. adults, 2.1 %; P <0.001). Conversely, patients who had any medical comorbidity were less likely to undergo MIS surgery (open, 26.2 % vs. MIS, 2.8 %; P = 0.002). In the propensity-matched cohort, MIS resection was associated with decreased length of stay (open, 7 days vs. MIS, 5 days), lower estimated blood loss (open, 50 mL vs. MIS, 17.5 mL), and longer operative time (open, 237 min vs. MIS, 301 min) compared with open surgery (all P <0.05). The overall and degree of complication did not differ between the open (grades I–II, n = 13; grades III–IV, n = 15) versus MIS (grades I–II, n = 5; grades III–IV, n = 5) cohorts (P = 0.85). Five-year overall survival was 98.6 % (open, 98.0 % vs. MIS, 100.0 %; P = 0.45); no patient who underwent MIS developed a subsequent cholangiocarcinoma. Conclusions: MIS resection of CC was demonstrated to be a feasible and safe approach with acceptable short-term outcomes in the pediatric population. MIS for benign CC disease was associated with similar perioperative morbidity but a shorter length of stay and a lower blood loss when compared with open resection.
AB - Background: The use of minimally invasive surgery (MIS) for choledochal cyst (CC) has not been well documented. We sought to define the overall utilization and outcomes associated with the use of the open versus MIS approach for CC. We examined the factors associated with receipt of MIS for CC, as well as characterized perioperative and long-term outcomes following open versus MIS for CC. Methods: Between 1972 and 2014, a total of 368 patients who underwent resection for CC were identified from an international, multicenter database. A 2:1 propensity score matching was used to create comparable cohorts of patients to assess the effect of MIS on short-term outcomes. Results: Three hundred thirty-two patients had an open procedure, whereas 36 patients underwent an MIS approach. Children were more likely to be treated with a MIS approach (children, 24.0 % vs. adults, 2.1 %; P <0.001). Conversely, patients who had any medical comorbidity were less likely to undergo MIS surgery (open, 26.2 % vs. MIS, 2.8 %; P = 0.002). In the propensity-matched cohort, MIS resection was associated with decreased length of stay (open, 7 days vs. MIS, 5 days), lower estimated blood loss (open, 50 mL vs. MIS, 17.5 mL), and longer operative time (open, 237 min vs. MIS, 301 min) compared with open surgery (all P <0.05). The overall and degree of complication did not differ between the open (grades I–II, n = 13; grades III–IV, n = 15) versus MIS (grades I–II, n = 5; grades III–IV, n = 5) cohorts (P = 0.85). Five-year overall survival was 98.6 % (open, 98.0 % vs. MIS, 100.0 %; P = 0.45); no patient who underwent MIS developed a subsequent cholangiocarcinoma. Conclusions: MIS resection of CC was demonstrated to be a feasible and safe approach with acceptable short-term outcomes in the pediatric population. MIS for benign CC disease was associated with similar perioperative morbidity but a shorter length of stay and a lower blood loss when compared with open resection.
KW - Choledochal cyst
KW - Laparoscopy
KW - Mini-invasive surgery
KW - Surgery
UR - http://www.scopus.com/inward/record.url?scp=84938097391&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938097391&partnerID=8YFLogxK
U2 - 10.1007/s11605-014-2722-y
DO - 10.1007/s11605-014-2722-y
M3 - Article
C2 - 25519084
AN - SCOPUS:84938097391
SN - 1091-255X
VL - 19
SP - 858
EP - 865
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
IS - 5
ER -