Minimal information about T cell assays: The process of reaching the community of T cell immunologists in cancer and beyond

C. M. Britten, S. Janetzki, S. H. Van Der Burg, C. Huber, M. Kalos, H. I. Levitsky, H. T. Maecker, C. J M Melief, J. O'Donnell-Tormey, K. Odunsi, L. J. Old, G. Pawelec, B. O. Roep, P. Romero, A. Hoos, M. M. Davis

Research output: Contribution to journalArticle

Abstract

Many assays to evaluate the nature, breadth, and quality of antigen-specific T cell responses are currently applied in human medicine. In most cases, assay-related protocols are developed on an individual laboratory basis, resulting in a large number of different protocols being applied worldwide. Together with the inherent complexity of cellular assays, this leads to unnecessary limitations in the ability to compare results generated across institutions. Over the past few years a number of critical assay parameters have been identified which influence test performance irrespective of protocol, material, and reagents used. Describing these critical factors as an integral part of any published report will both facilitate the comparison of data generated across institutions and lead to improvements in the assays themselves. To this end, the Minimal Information About T Cell Assays (MIATA) project was initiated. The objective of MIATA is to achieve a broad consensus on which T cell assay parameters should be reported in scientific publications and to propose a mechanism for reporting these in a systematic manner. To add maximum value for the scientific community, a step-wise, open, and field-spanning approach has been taken to achieve technical precision, user-friendliness, adequate incorporation of concerns, and high acceptance among peers. Here, we describe the past, present, and future perspectives of the MIATA project. We suggest that the approach taken can be generically applied to projects in which a broad consensus has to be reached among scientists working in fragmented fields, such as immunology. An additional objective of this undertaking is to engage the broader scientific community to comment on MIATA and to become an active participant in the project.

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalCancer Immunology Immunotherapy
Volume60
Issue number1
DOIs
StatePublished - Jan 2011

Fingerprint

T-Lymphocytes
Neoplasms
Allergy and Immunology
Publications
Medicine
Antigens

Keywords

  • Immune monitoring
  • MIATA
  • Minimal information about T cell assays
  • Reporting guidelines

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Immunology
  • Immunology and Allergy

Cite this

Britten, C. M., Janetzki, S., Van Der Burg, S. H., Huber, C., Kalos, M., Levitsky, H. I., ... Davis, M. M. (2011). Minimal information about T cell assays: The process of reaching the community of T cell immunologists in cancer and beyond. Cancer Immunology Immunotherapy, 60(1), 15-22. https://doi.org/10.1007/s00262-010-0940-z

Minimal information about T cell assays : The process of reaching the community of T cell immunologists in cancer and beyond. / Britten, C. M.; Janetzki, S.; Van Der Burg, S. H.; Huber, C.; Kalos, M.; Levitsky, H. I.; Maecker, H. T.; Melief, C. J M; O'Donnell-Tormey, J.; Odunsi, K.; Old, L. J.; Pawelec, G.; Roep, B. O.; Romero, P.; Hoos, A.; Davis, M. M.

In: Cancer Immunology Immunotherapy, Vol. 60, No. 1, 01.2011, p. 15-22.

Research output: Contribution to journalArticle

Britten, CM, Janetzki, S, Van Der Burg, SH, Huber, C, Kalos, M, Levitsky, HI, Maecker, HT, Melief, CJM, O'Donnell-Tormey, J, Odunsi, K, Old, LJ, Pawelec, G, Roep, BO, Romero, P, Hoos, A & Davis, MM 2011, 'Minimal information about T cell assays: The process of reaching the community of T cell immunologists in cancer and beyond', Cancer Immunology Immunotherapy, vol. 60, no. 1, pp. 15-22. https://doi.org/10.1007/s00262-010-0940-z
Britten, C. M. ; Janetzki, S. ; Van Der Burg, S. H. ; Huber, C. ; Kalos, M. ; Levitsky, H. I. ; Maecker, H. T. ; Melief, C. J M ; O'Donnell-Tormey, J. ; Odunsi, K. ; Old, L. J. ; Pawelec, G. ; Roep, B. O. ; Romero, P. ; Hoos, A. ; Davis, M. M. / Minimal information about T cell assays : The process of reaching the community of T cell immunologists in cancer and beyond. In: Cancer Immunology Immunotherapy. 2011 ; Vol. 60, No. 1. pp. 15-22.
@article{26303edf4f4f41f49ba5e1f69996d062,
title = "Minimal information about T cell assays: The process of reaching the community of T cell immunologists in cancer and beyond",
abstract = "Many assays to evaluate the nature, breadth, and quality of antigen-specific T cell responses are currently applied in human medicine. In most cases, assay-related protocols are developed on an individual laboratory basis, resulting in a large number of different protocols being applied worldwide. Together with the inherent complexity of cellular assays, this leads to unnecessary limitations in the ability to compare results generated across institutions. Over the past few years a number of critical assay parameters have been identified which influence test performance irrespective of protocol, material, and reagents used. Describing these critical factors as an integral part of any published report will both facilitate the comparison of data generated across institutions and lead to improvements in the assays themselves. To this end, the Minimal Information About T Cell Assays (MIATA) project was initiated. The objective of MIATA is to achieve a broad consensus on which T cell assay parameters should be reported in scientific publications and to propose a mechanism for reporting these in a systematic manner. To add maximum value for the scientific community, a step-wise, open, and field-spanning approach has been taken to achieve technical precision, user-friendliness, adequate incorporation of concerns, and high acceptance among peers. Here, we describe the past, present, and future perspectives of the MIATA project. We suggest that the approach taken can be generically applied to projects in which a broad consensus has to be reached among scientists working in fragmented fields, such as immunology. An additional objective of this undertaking is to engage the broader scientific community to comment on MIATA and to become an active participant in the project.",
keywords = "Immune monitoring, MIATA, Minimal information about T cell assays, Reporting guidelines",
author = "Britten, {C. M.} and S. Janetzki and {Van Der Burg}, {S. H.} and C. Huber and M. Kalos and Levitsky, {H. I.} and Maecker, {H. T.} and Melief, {C. J M} and J. O'Donnell-Tormey and K. Odunsi and Old, {L. J.} and G. Pawelec and Roep, {B. O.} and P. Romero and A. Hoos and Davis, {M. M.}",
year = "2011",
month = "1",
doi = "10.1007/s00262-010-0940-z",
language = "English (US)",
volume = "60",
pages = "15--22",
journal = "Cancer Immunology and Immunotherapy",
issn = "0340-7004",
publisher = "Springer Science and Business Media Deutschland GmbH",
number = "1",

}

TY - JOUR

T1 - Minimal information about T cell assays

T2 - The process of reaching the community of T cell immunologists in cancer and beyond

AU - Britten, C. M.

AU - Janetzki, S.

AU - Van Der Burg, S. H.

AU - Huber, C.

AU - Kalos, M.

AU - Levitsky, H. I.

AU - Maecker, H. T.

AU - Melief, C. J M

AU - O'Donnell-Tormey, J.

AU - Odunsi, K.

AU - Old, L. J.

AU - Pawelec, G.

AU - Roep, B. O.

AU - Romero, P.

AU - Hoos, A.

AU - Davis, M. M.

PY - 2011/1

Y1 - 2011/1

N2 - Many assays to evaluate the nature, breadth, and quality of antigen-specific T cell responses are currently applied in human medicine. In most cases, assay-related protocols are developed on an individual laboratory basis, resulting in a large number of different protocols being applied worldwide. Together with the inherent complexity of cellular assays, this leads to unnecessary limitations in the ability to compare results generated across institutions. Over the past few years a number of critical assay parameters have been identified which influence test performance irrespective of protocol, material, and reagents used. Describing these critical factors as an integral part of any published report will both facilitate the comparison of data generated across institutions and lead to improvements in the assays themselves. To this end, the Minimal Information About T Cell Assays (MIATA) project was initiated. The objective of MIATA is to achieve a broad consensus on which T cell assay parameters should be reported in scientific publications and to propose a mechanism for reporting these in a systematic manner. To add maximum value for the scientific community, a step-wise, open, and field-spanning approach has been taken to achieve technical precision, user-friendliness, adequate incorporation of concerns, and high acceptance among peers. Here, we describe the past, present, and future perspectives of the MIATA project. We suggest that the approach taken can be generically applied to projects in which a broad consensus has to be reached among scientists working in fragmented fields, such as immunology. An additional objective of this undertaking is to engage the broader scientific community to comment on MIATA and to become an active participant in the project.

AB - Many assays to evaluate the nature, breadth, and quality of antigen-specific T cell responses are currently applied in human medicine. In most cases, assay-related protocols are developed on an individual laboratory basis, resulting in a large number of different protocols being applied worldwide. Together with the inherent complexity of cellular assays, this leads to unnecessary limitations in the ability to compare results generated across institutions. Over the past few years a number of critical assay parameters have been identified which influence test performance irrespective of protocol, material, and reagents used. Describing these critical factors as an integral part of any published report will both facilitate the comparison of data generated across institutions and lead to improvements in the assays themselves. To this end, the Minimal Information About T Cell Assays (MIATA) project was initiated. The objective of MIATA is to achieve a broad consensus on which T cell assay parameters should be reported in scientific publications and to propose a mechanism for reporting these in a systematic manner. To add maximum value for the scientific community, a step-wise, open, and field-spanning approach has been taken to achieve technical precision, user-friendliness, adequate incorporation of concerns, and high acceptance among peers. Here, we describe the past, present, and future perspectives of the MIATA project. We suggest that the approach taken can be generically applied to projects in which a broad consensus has to be reached among scientists working in fragmented fields, such as immunology. An additional objective of this undertaking is to engage the broader scientific community to comment on MIATA and to become an active participant in the project.

KW - Immune monitoring

KW - MIATA

KW - Minimal information about T cell assays

KW - Reporting guidelines

UR - http://www.scopus.com/inward/record.url?scp=79953750263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953750263&partnerID=8YFLogxK

U2 - 10.1007/s00262-010-0940-z

DO - 10.1007/s00262-010-0940-z

M3 - Article

C2 - 21080166

AN - SCOPUS:79953750263

VL - 60

SP - 15

EP - 22

JO - Cancer Immunology and Immunotherapy

JF - Cancer Immunology and Immunotherapy

SN - 0340-7004

IS - 1

ER -