Abstract
Secreted membrane-enclosed vesicles, collectively called extracellular vesicles (EVs), which include exosomes, ectosomes, microvesicles, microparticles, apoptotic bodies and other EV subsets, encompass a very rapidly growing scientific field in biology and medicine. Importantly, it is currently technically challenging to obtain a totally pure EV fraction free from non-vesicular components for functional studies, and therefore there is a need to establish guidelines for analyses of these vesicles and reporting of scientific studies on EV biology. Here, the International Society for Extracellular Vesicles (ISEV) provides researchers with a minimal set of biochemical, biophysical and functional standards that should be used to attribute any specific biological cargo or functions to EVs.
Original language | English (US) |
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Article number | 26913 |
Journal | Journal of Extracellular Vesicles |
Volume | 3 |
Issue number | 1 |
DOIs | |
State | Published - 2014 |
Keywords
- Ectosomes
- Exosomes
- Extracellular RNA
- Extracellular vesicles
- Microparticles
- Microvesicles
ASJC Scopus subject areas
- Histology
- Cell Biology