Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats

Alexis M. Stranahan, Thiruma V. Arumugam, Kim Lee, Mark P. Mattson

Research output: Contribution to journalArticle

Abstract

In the hippocampus, glucocorticoids bind to two types of receptors: the mineralocorticoid receptor, which binds corticosterone with high affinity and is tonically occupied; and the glucocorticoid receptor, which is occupied during stress and at certain phases in the circadian cycle. Diabetes mellitus increases levels of glucocorticoids in both humans and animal models. To explore the contributions of hippocampal corticosteroid receptors to the diabetes-induced suppression of neuroplasticity, we manipulated these receptors in hippocampal slices from streptozocin-diabetic rats, a model of Type 1 diabetes mellitus. STZ-diabetes reduced long-term potentiation (LTP) at medial perforant path synapses in the dentate gyrus, and induced a bias in favor of long-term depression following intermediate stimulation frequencies. Bath application of the mineralocorticoid receptor agonist aldosterone restored LTP in slices from diabetic animals. These results suggest additional mechanisms for diabetes-induced functional alterations and support a restorative role for dentate gyrus mineralocorticoid receptors.

Original languageEnglish (US)
Pages (from-to)528-532
Number of pages5
JournalSynapse
Volume64
Issue number7
DOIs
StatePublished - Jul 2010
Externally publishedYes

Fingerprint

Perforant Pathway
Mineralocorticoid Receptors
Long-Term Potentiation
Dentate Gyrus
Glucocorticoids
Neuronal Plasticity
Steroid Receptors
Glucocorticoid Receptors
Streptozocin
Corticosterone
Aldosterone
Type 1 Diabetes Mellitus
Baths
Synapses
Hippocampus
Diabetes Mellitus
Animal Models

Keywords

  • Aldosterone
  • Corticosterone
  • Diabetes
  • Glucocorticoid
  • Hippocampus

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Stranahan, A. M., Arumugam, T. V., Lee, K., & Mattson, M. P. (2010). Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats. Synapse, 64(7), 528-532. https://doi.org/10.1002/syn.20758

Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats. / Stranahan, Alexis M.; Arumugam, Thiruma V.; Lee, Kim; Mattson, Mark P.

In: Synapse, Vol. 64, No. 7, 07.2010, p. 528-532.

Research output: Contribution to journalArticle

Stranahan, AM, Arumugam, TV, Lee, K & Mattson, MP 2010, 'Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats', Synapse, vol. 64, no. 7, pp. 528-532. https://doi.org/10.1002/syn.20758
Stranahan, Alexis M. ; Arumugam, Thiruma V. ; Lee, Kim ; Mattson, Mark P. / Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats. In: Synapse. 2010 ; Vol. 64, No. 7. pp. 528-532.
@article{00651656dcb345cba666e4a8ab03b889,
title = "Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats",
abstract = "In the hippocampus, glucocorticoids bind to two types of receptors: the mineralocorticoid receptor, which binds corticosterone with high affinity and is tonically occupied; and the glucocorticoid receptor, which is occupied during stress and at certain phases in the circadian cycle. Diabetes mellitus increases levels of glucocorticoids in both humans and animal models. To explore the contributions of hippocampal corticosteroid receptors to the diabetes-induced suppression of neuroplasticity, we manipulated these receptors in hippocampal slices from streptozocin-diabetic rats, a model of Type 1 diabetes mellitus. STZ-diabetes reduced long-term potentiation (LTP) at medial perforant path synapses in the dentate gyrus, and induced a bias in favor of long-term depression following intermediate stimulation frequencies. Bath application of the mineralocorticoid receptor agonist aldosterone restored LTP in slices from diabetic animals. These results suggest additional mechanisms for diabetes-induced functional alterations and support a restorative role for dentate gyrus mineralocorticoid receptors.",
keywords = "Aldosterone, Corticosterone, Diabetes, Glucocorticoid, Hippocampus",
author = "Stranahan, {Alexis M.} and Arumugam, {Thiruma V.} and Kim Lee and Mattson, {Mark P.}",
year = "2010",
month = "7",
doi = "10.1002/syn.20758",
language = "English (US)",
volume = "64",
pages = "528--532",
journal = "Synapse",
issn = "0887-4476",
publisher = "Wiley-Liss Inc.",
number = "7",

}

TY - JOUR

T1 - Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats

AU - Stranahan, Alexis M.

AU - Arumugam, Thiruma V.

AU - Lee, Kim

AU - Mattson, Mark P.

PY - 2010/7

Y1 - 2010/7

N2 - In the hippocampus, glucocorticoids bind to two types of receptors: the mineralocorticoid receptor, which binds corticosterone with high affinity and is tonically occupied; and the glucocorticoid receptor, which is occupied during stress and at certain phases in the circadian cycle. Diabetes mellitus increases levels of glucocorticoids in both humans and animal models. To explore the contributions of hippocampal corticosteroid receptors to the diabetes-induced suppression of neuroplasticity, we manipulated these receptors in hippocampal slices from streptozocin-diabetic rats, a model of Type 1 diabetes mellitus. STZ-diabetes reduced long-term potentiation (LTP) at medial perforant path synapses in the dentate gyrus, and induced a bias in favor of long-term depression following intermediate stimulation frequencies. Bath application of the mineralocorticoid receptor agonist aldosterone restored LTP in slices from diabetic animals. These results suggest additional mechanisms for diabetes-induced functional alterations and support a restorative role for dentate gyrus mineralocorticoid receptors.

AB - In the hippocampus, glucocorticoids bind to two types of receptors: the mineralocorticoid receptor, which binds corticosterone with high affinity and is tonically occupied; and the glucocorticoid receptor, which is occupied during stress and at certain phases in the circadian cycle. Diabetes mellitus increases levels of glucocorticoids in both humans and animal models. To explore the contributions of hippocampal corticosteroid receptors to the diabetes-induced suppression of neuroplasticity, we manipulated these receptors in hippocampal slices from streptozocin-diabetic rats, a model of Type 1 diabetes mellitus. STZ-diabetes reduced long-term potentiation (LTP) at medial perforant path synapses in the dentate gyrus, and induced a bias in favor of long-term depression following intermediate stimulation frequencies. Bath application of the mineralocorticoid receptor agonist aldosterone restored LTP in slices from diabetic animals. These results suggest additional mechanisms for diabetes-induced functional alterations and support a restorative role for dentate gyrus mineralocorticoid receptors.

KW - Aldosterone

KW - Corticosterone

KW - Diabetes

KW - Glucocorticoid

KW - Hippocampus

UR - http://www.scopus.com/inward/record.url?scp=77953844755&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953844755&partnerID=8YFLogxK

U2 - 10.1002/syn.20758

DO - 10.1002/syn.20758

M3 - Article

VL - 64

SP - 528

EP - 532

JO - Synapse

JF - Synapse

SN - 0887-4476

IS - 7

ER -